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008			230324s2023 ne | o |||| 0|eng d
020			_a9789402411911
024	7		_a10.1007/978-94-024-1191-1 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRS164 _b2023 EB
100	1		_aRobinson, Brian _eautor _9689973 _q(Brian Henrie)
245	1	0	_aThe Calabar Bean and its Alkaloids : _bFrom Magic, via Miracle, to Memory _cby Brian Robinson
250			_a1st ed. 2023
264		1	_aDordrecht _bSpringer Netherlands _c2023
300			_a1 recurso en línea
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aChronology -- Abbreviations -- Preface and acknowledgements -- 1. Introduction -- 2. l-Physostigmine (eserine) -- 3. l-Physovenine -- 4. l-Eseramine -- 5. l-N(8)-Norphysostigmine -- 6. l-Geneserine -- 7. 1H-, 13C- and 15N-Nuclear magnetic resonance spectra of the alkaloids of the Calabar bean -- 8. Other alkaloids of, as yet, unknown structures that have been isolated, or allegedly so, from the Calabar bean -- 9. Non-alkaloidal components of the Calabar bean -- 10. Biological activities of the alkaloids of the Calabar bean -- 11. Notes -- 12. References -- 13. Index.
520			_aInvestigations into Calabar beans (the dried ripe seeds of Physostigma venenosum) and their alkaloidal components compose a classical scientific journey throughout some one-and-a-half centuries and not only represent a fascinating aspect of the history of medicine but which is, moreover, still ongoing at the forefront of chemical and medical discovery. Those in particular involving its major such component, l-physostigmine, have led to an understanding of some of the fundamental mechanisms occurring in physiology, pharmacology and biochemistry and, either actually or potentially (by providing a template and thereby acting as a "lead compound") have provided a useful treatment for a variety of neurological disorders associated with irregularities in cholinergic transmission in which augmentation of cholinergic activity has proved to be beneficial.
988			_aSpringer_BiomedLife_2023
650		7	_2embne _9404971 _aPlantas medicinales
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-94-024-1191-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b04/2024 _dz _eu _zSI