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008			230425s2023 sz | o |||| 0|eng d
020			_a9783031290299
024	7		_a10.1007/978-3-031-29029-9 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQP552 .T68 _b2023 EB
100	1		_aLi, Willis X. _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9689845
245	1	4	_aThe Secret Lives of Transcription Factors : _bIn Heterochromatin Regulation _cby Willis X Li, Louise Silver-Morse
250			_a1st ed. 2023
264		1	_aCham _bSpringer International Publishing _c2023
300			_a1 recurso en línea
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aSpringerBriefs in Biochemistry and Molecular Biology _x2211-9361
505	0		_aChapter 1 Introduction -- Chapter 2 Unconventional functions of transcription factors -- GAGA transcription factor -- Heterochromatin protein 1 -- Retinoblastoma protein -- STAT -- ATF-2 -- NF-kB -- Chapter 3 STAT and HP1, in their unconventional roles, promote longevity and protect against DNA damage and cancer -- STAT and HP1 promote longevity -- STAT and HP1 protect against DNA damage -- Increased levels of STAT and HP1 hinder carcinogenesis in a mouse xenograft model -- Chapter 4 The possible biological significance of transcription factors' unconventional functions -- The epigenome -- Processes in the cell nucleus -- Future Work.
520			_aThis SpringerBrief explores unconventional functions of eight different transcription factors and concludes with a discussion of their biological significance and impact, including effects on processes within the cell nucleaus during development and in adult organisms. Chapter One details unconventional functions of the transcription factors GAGA, HP1, Rb, STAT, ATF-2 and NF-kB. Surprisingly, all of these transcription factors can be found in association with heterochromatin as well as euchromatin, and in some cases unconventional functions have been demonstrated for these heterochromatin-associated factors. Chapter Two focuses on the unconventional functions of STAT and HP1 and discusses their roles in the promotion of longevity, and in protection from cancer and DNA damage. Chapter Three explores the biological significance of the findings presented in the first two chapters and considers how global changes in the epigenome brought about by factors such as STAT and HP1 might affect processes within the cell nucleus during development and in adult organisms. This succinct yet thorough SpringerBrief is essential for researchers studying epigenetics, and to instructors of the subject. It should also appeal to people interested in the control of gene transcription and other processes in the cell nucleus, and to those interested in development.
988			_aSpringer_BiomedLife_2023
650		7	_2embne _9147235 _aTranscripción genética
700	1		_9689846 _aSilver-Morse, Louise _eautor
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-031-29029-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b03/2024 _dz _eb _zSI