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008			221215s2023 sz | o |||| 0|eng d
020			_a9783031218200
024	7		_a10.1007/978-3-031-21820-0 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQH442 _b2023 EB
100	1		_aParis, Katherine _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9689812
245	1	0	_aGenome Editing and Biological Weapons : _bAssessing the Risk of Misuse _cby Katherine Paris
250			_a1st ed. 2023
264		1	_aCham _bSpringer International Publishing _c2023
300			_a1 recurso en línea
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aChapter 1: Introduction: Rapid Technological Advancements amid Rising Concerns of Misuse -- Chapter 2: Background: Genome Editing with Programmable Nucleases -- Chapter 3: Applying Genetic Engineering to Biological Weapons -- Chapter 4: Risk of Misuse Assessment: Part I -- Chapter 5: Risk of Misuse Assessment: Part II -- Chapter 6: Raising the Alarm on CRISPR -- Chapter 7: Conclusion: Reducing the Perils from the Misuse of Genome Editing.
520			_aThis monograph introduces current genome editing technologies-clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated (Cas) systems, transcription activator-like effector nucleases (TALENs), and zinc-finger nucleases (ZFNs)-and provides an assessment of the risk of misuse of these technologies based on the following parameters: accessibility, ease of misuse, magnitude of potential harm, and imminence of potential misuse. The findings from this assessment are applied to analyze and evaluate the threat posed by the intentional misuse of genome editing technologies to develop biological weapons. Furthermore, the book discusses the implications of misuse for different applications of genome editing, such as making existing pathogens more dangerous, modifying the human microbiome, weaponizing gene drives, engineering super soldiers, and augmenting the general population to confer economic advantages. Technologies that enable genome editing with programmable nucleases-including CRISPR, TALEN, and ZFN-allow for the precise genetic modification of organisms and cultured cells. While these technologies are used for a variety of beneficial applications, intelligence and defense experts have raised concerns that genome editing technologies, especially CRISPR, could be misused to develop new and improved biological weapons. Furthermore, experts worry that the number and type of actors who could potentially misuse genome editing is dramatically increasing given the democratization of biology, which is allowing biology to become more accessible to everyone including nonexperts. The book provides a comprehensive assessment of how feasible it is for users with different levels of knowledge and skill to acquire and then to apply the technologies to develop a biological weapon. It also provides an assessment of governability and a tailored set of recommendations that address security concerns. These recommendations are sensitive to the cost-benefit trade-off of regulating genome editing technologies. The book targets researchers as well as intelligence analysts, defense and security personnel, and policymakers. .
988			_aSpringer_BiomedLife_2023
650		7	_2embne _9141520 _aIngeniería genética
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-031-21820-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b03/2024 _dz _eb _zSI