000			02826nam a2200325 i 4500
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003			ES-MaUEC
005			20240316123023.0
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007			cr nn 008mamaa
008			230418s2023 si | o |||| 0|eng d
020			_a9789811956386
024	7		_a10.1007/978-981-19-5638-6 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRS201 .A56 _b2023 EB
245	0	0	_aAntibody-Drug Conjugates and Cellular Metabolic Dynamics _cedited by Shuqing Chen, Jinbiao Zhan
250			_a1st ed. 2023
264		1	_aSingapore _bSpringer Nature Singapore _c2023
300			_a1 recurso en línea
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aAntibody-Drug Conjugates Basic Concepts and Structures -- Relationship between target and specific action of antibody-drugs conjugates -- The internalization and therapeutic activity of antibody drug conjugate -- The internalization and intracellular trafficking of ADC -- Distribution and metabolism of antibody-drug conjugates -- Application of Antibody fragments in ADCs -- Novel Targeting Carriers in Antibody-drug Conjugates -- Site-specified Conjugating Technology and Application -- Determination of drug-to-antibody ratio of ADCs -- Pharmacokinetic study of antibody-drug conjugates.
520			_aThis book summarizes the related research achievements in Antibody-drug conjugates (ADCs) and their cell metabolism kinetics. The book has three main parts. The first part describes the basic theory of ADCs, including the basic concept and structure of ADCs, and the relationship between the targets of ADCs and their specific functions. The second part mainly introduces the endocytosis and intracellular metabolism of ADCs, including the relationship between endocytosis and ADC activity, the endocytosis and intracellular transport of ADCs, the distribution and metabolism of ADC in vivo. Then it discusses the new formats and research technology of ADCs, including the application of miniaturized antibodies in ADC synthesis, novel carriers for ADC design, the technology and application of site-specific conjugation, and approaches for analyzing the drug: antibody ratio (DAR), the study of pharmacokinetics of ADCs. This book combines the basic theory with the research technology. It can be used as a reference book for students, teachers and researchers of biomedical field.
988			_aSpringer_BiomedLife_2023
650		7	_2embne _9405730 _aAnticuerpos monoclonales
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-19-5638-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b03/2024 _dz _eb _zSI