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020 _a9781071622650
024 7 _a10.1007/978-1-0716-2265-0
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
_dES-MaUEC
050 4 _aR855
_b2022 EB
245 0 0 _aSystems Medicine
_cedited by Jane P. F. Bai, Junguk Hur
250 _a1st edition 2022
264 1 _aNew York, NY
_bSpringer International Publising
_c2022
300 _a1 recurso en línea (XIII, 347 páginas)
_b68 ilustraciones, 59 ilustraciones a color
336 _atexto
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
490 0 _aMethods in Molecular Biology
_x1940-6029
_v2486
505 0 _aMass Spectrometry-Based Proteomics for Biomarker Discovery -- Integration of Omics and Phenotypic Data for Precision Medicine -- Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in the Era of Systems Medicine -- Integration of Engineered Delivery with the Pharmacokinetics of Medical Candidates via Physiology-Based Pharmacokinetics -- Applications of Quantitative System Pharmacology Modeling to Model Informed Drug Development -- Combating Viral Diseases in the Era of Systems Medicine -- Toxicity Analysis of Pentachlorophenol Data with a Bioinformatics Tool Set -- Virtual Populations for Quantitative Systems Pharmacology Models -- Quantitative Systems Toxicology and Drug Development: The DILIsym Experience -- Introduction to Genomic Network Reconstruction for Cancer Research -- Learning in Medicine: The Importance of Statistical Thinking -- Development and Applications of Interoperable Biomedical Ontologies for Integrative Data and Knowledge Representation and Multiscale Modeling in Systems Medicine -- Systems Biology to Address Unmet Medical Needs in Neurological Disorders -- Informatics in Medical Product Regulation: The Right Drug at the Right Dose for the Right Patient -- Personal Dense Dynamic Data Clouds Connect Systems Bio-Medicine to Scientific Wellness -- Educational Needs for Quantitative Systems Pharmacology Scientists.
520 _aThis volume explores the latest technological advances and covers all facets of systems medicine with respect to precision medicine. The chapters in this book are organized into four parts. Part One highlights the recent achievements in proteomics for biomarkers identification, integration of omics and phenotypic data for precision medicine, and medicine-guided treatment of drug-induced Stevens-Johnson syndrome. Part Two covers systems-based computational approaches for pharmaceutical research and drug development, the principle of optimizing systemic exposure of drugs, and Animal Rule for drug repurposing. Part Three looks at computational tools and methodologies of network biology, quantitative systems toxicology, and modeling and stimulating patient response variabilities. Part Four talks about how systems medicine can address unmet medical and health needs, and identify educational needs. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Systems Medicine: Methods and Protocols is a valuable resource for the scientific community that will help researchers work together toward the further advancement of achieving the goal of promoting global health. Chapter 8 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
988 _aSpringer_Protocols_2022
650 7 _2embne
_9150466
_aTecnología médica
776 0 8 _iPrinted edition:
_z9781071622643
776 0 8 _iPrinted edition:
_z9781071622667
776 0 8 _iPrinted edition:
_z9781071622674
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-0716-2265-0
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942 _2lcc
_cLE
998 _b07/2023
_dz
_eb
_zSI