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008			220316s2022 xxua o |||| 0|eng d
020			_a9781071622131
024	7		_a10.1007/978-1-0716-2213-1 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRA1199 _b2022 EB
245	0	0	_aHigh-Throughput Screening Assays in Toxicology _cedited by Hao Zhu, Menghang Xia
250			_a2nd edition 2022
264		1	_aNew York, NY _bSpringer International Publising _c2022
300			_a1 recurso en línea (XII, 200 páginas) _b54 ilustraciones, 32 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v2474
505	0		_aCell-Based Assays to Identify ERR and ERR/PGC Modulators -- Mitochondrial Membrane Potential Assay -- Cell-Based hERG Inhibition Assay in a High-Throughput Format -- Identifying CAR Modulators Utilizing a Reporter Gene Assay -- Study Liver Cytochrome P450 3A4 Inhibition and Hepatotoxicity Using DMSO-Differentiated HuH-7 Cells -- Acetylcholinesterase Inhibition Assays for High-Throughput Screening -- Cell-Based Assays to Identify Modulators of Nrf2/ARE Pathway -- Cell-Based Imaging Assay for Detection of Phospholipdosis -- GFP-LC3 High-Content Assay for Screening Autophagy Modulators -- Generation of iPSC-Derived Brain Organoids for Drug Testing and Toxicological Evaluation -- Zebrafish Behavioral Assays in Toxicology -- High Throughput Screening Assay Profiling for Large Chemical Databases -- A Quantitative High Throughput Screening Data Analysis Pipeline for Activity Profiling -- CurveP Method for Rendering High Throughput Screening Dose-Response Data into Digital Fingerprints -- Accounting for Artifacts in High Throughput Toxicity Assays -- Automatic Quantitative Structure-Activity Relationship Modeling to Fill Data Gaps in High-Throughput Screening -- Use In Silico and In Vitro Methods to Screen Hepatotoxic Chemicals and CYP450 Enzyme Inhibitors.
520			_aThis second edition volume expands on the previous edition by exploring the latest advancements in high throughput screening (HTS) in toxicity studies by using in vitro, ex vivo, and in vivo models. This volume also covers the application of artificial intelligence (AI) and data science to curate, manage, and use HTS data. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, High Throughput Screening Assays in Modern Toxicology, Second Edition is a valuable resource for scientists pursuing chemical toxicology research. This book will aid scientists and researchers in translating new HTS techniques into standardized chemical toxicology assessment tools that can refine, reduce, and replace animal testing. .
988			_aSpringer_Protocols_2022
650		7	_2embne _9685999 _aEnsayos de toxicidad
776	0	8	_iPrinted edition: _z9781071622124
776	0	8	_iPrinted edition: _z9781071622148
776	0	8	_iPrinted edition: _z9781071622155
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-0716-2213-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b07/2023 _dz _eb _zSI