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008			220622s2022 xxu| o |||| 0|eng d
020			_a9781071622896
024	7		_a10.1007/978-1-0716-2289-6 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQP370 _b2022 EB
245	0	4	_aThe Blood-Brain Barrier : _bMethods and Protocols _cedited by Nicole Stone
250			_a1st edition 2022
264		1	_aNew York, NY _bSpringer International Publising _c2022
300			_a1 recurso en línea (XI, 357 páginas) _b83 ilustraciones, 73 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v2492
505	0		_aCells of the Blood-Brain Barrier: An Overview of the Neurovascular Unit in Health and Disease -- In Vitro Models of the Blood-Brain Barrier -- In Vitro Models of the Human Blood-Brain Barrier Based on Human Induced Pluripotent Stem Cells: Opportunities and Challenges -- Induced Pluripotent Stem Cell (iPSC)-Derived Endothelial Cells to Study Bacterial-Brain Endothelial Cell Interactions -- An hiPSC-Derived In Vitro Model of the Blood-Brain Barrier -- A Three-Dimensional Brain-on-Chip Using Human iPSC-Derived GABAergic Neurons and Astrocytes -- An Improved In Vitro Porcine Blood-Brain Barrier Model for Permeability Screening and Functional Studies -- Establishment of an In Vitro Model of Human Blood-Brain Barrier to Study the Impact of Ischaemic Injury -- A Novel Dynamic Human In Vitro Model for Studying the Blood-Brain Barrier -- A Dynamic, In Vitro BBB Model to Study the Effects of Varying Levels of Shear Stress -- Novel, Emerging Chip Models of the BBB and Future Directions -- Integrating Primary Astrocytes in a Microfluidic Model of the Blood-Brain Barrier -- Fabrication of Microtube-Embedded Chip to Mimic Blood-Brain Barrier Capillary Vessels -- BBB-on-a-Chip: Modeling Functional Human BBB by Mimicking 3D Brain Angiogenesis Using Microfluidic Chip -- Cell Interplay Model to Assess the Impact of Glioma Cells on Blood-Brain Barrier Permeability -- An In Vitro Human Blood-Brain Barrier Model to Study Breast Cancer Brain Metastasis -- An In Vivo Mouse Model to Study Blood-Brain Barrier Destabilization in the Chronic Phase of Stroke -- Immunohistochemical Analysis of Tight Junction Proteins -- An In Vitro BBB Model to Study Firm Shear-Stress Resistant Leukocyte Adhesion to Human Brain Endothelial Cells -- An In Vitro Model of the Blood-Brain Barrier (BBB) to Study Alzheimer's Disease: The Role of β-Amyloid and Its Influence on PBMC Infiltration.
520			_aThis detailed volume features techniques to explore the complex interface that separates the systemic circulation from the central nervous system, known as the blood-brain barrier (BBB). Beginning with an introduction to its physiology, the book continues with sections on using pluripotent stem cells in models of the BBB, co-culture, permeability and transwell models, microfluidic and chip models, as well as models to study specific BBB pathologies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, The Blood-Brain Barrier: Methods and Protocols collects a wide range of methodologies which will aid all researchers in the fascinating world of the blood-brain barrier.
988			_aSpringer_Protocols_2022
650		7	_2embne _9144873 _aSistema nervioso central
650		7	_2embne _9147395 _aCirculación sanguínea cerebral
776	0	8	_iPrinted edition: _z9781071622889
776	0	8	_iPrinted edition: _z9781071622902
776	0	8	_iPrinted edition: _z9781071622919
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-0716-2289-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b07/2023 _dz _eu _zSI