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020			_a9783030871048
024	7		_a10.1007/978-3-030-87104-8 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC732 _b2022 EB
245	0	4	_aThe Microbiome in Respiratory Disease : _bPrinciples, Tools and Applications _cedited by Yvonne J. Huang, Stavros Garantziotis
250			_a1st edition 2022
264		1	_aCham _bSpringer International Publishing _c2022
300			_a1 recurso en línea (XI, 305 páginas) _b16 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aRespiratory Medicine _x2197-7380
505	0		_aSECTION I: Principles and Tools of Respiratory Microbiome Investigation -- Conceptual Framework and Hypothesis Testing -- Study Design and Sampling Considerations -- Laboratory Platforms to Study the Microbiome -- Analysis and Reporting of Microbiome Data -- SECTION II: Applications in the Study of Specific Diseases -- Chronic Rhinosinusitis /Allergic Rhinitis -- Bronchiolitis, Viral Infection and Pediatric Asthma Risk -- Asthma Pheotype -- Cystic Fibrosis -- Bronchiectasis (non-CF) -- COPD -- Idiopathic Pulmonary Fibrosis -- Lung Transplantation and Immune Suppression -- The Future: Knowledge gaps and priorities.
520			_aThis book comprehensively covers the microbiome in respiratory disease, from the initial research study to the disease-specific implications and related applications. Research on the respiratory microbiome is increasing in volume and scope. This reflects rapidly growing interest in the study of respiratory disease to understand how microbiota shape mechanisms of disease pathogenesis. The respiratory tract spans the nasal passages, sinus cavities, oropharynx, and the tracheobronchial tree of the lungs. In these compartments of the upper and lower respiratory tract, the microbiota have now been studied in the context of several chronic respiratory conditions. These include chronic sinusitis, allergic rhinitis, asthma, chronic obstructive pulmonary disease (COPD), bronchiectasis and pulmonary fibrosis, to name a few. The potential impact of ecological interactions (i.e., between microbes and between microbiota and host) within and across respiratory compartments is increasingly recognized. The book is organized into two main sections. Part I, Principles and Tools, covers conceptual modeling of the respiratory microbiome, experimental methodology with a focus on a priori considerations in study design and sampling, laboratory and computational methods for analysis of respiratory microbiome data, and minimizing interpretive pitfalls. Part II, Applications, discusses the evidence from specific studies that have shed novel insights into the influence of respiratory microbiota on mechanisms or outcomes in specific diseases. Based on current best evidence, disease-specific chapters include chronic rhinosinusitis, asthma (pediatric and adult studies), chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), bronchiectasis not due to CF, idiopathic pulmonary fibrosis, and lung transplant. This is an ideal reference for forward-thinking practitioners with interest in novel developments in precision medicine applications in lung disease, as well as translational scientists in the field of microbiology, immunology and lung biology. .
988			_aSpringer_Medicine_2022
650		7	_2embne _9405936 _aAparato respiratorio _xEnfermedades
650		7	_2embne _9405049 _aMicrobiología médica
776	0	8	_iPrinted edition: _z9783030871031
776	0	8	_iPrinted edition: _z9783030871055
776	0	8	_iPrinted edition: _z9783030871062
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-87104-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b01/2023 _dz _eb _zSI