000			04631nam a2200433 i 4500
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003			ES-MaUEC
005			20230113115319.0
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007			cr nn 008mamaa
008			211127s2022 sz a o |||| 0|eng d
020			_a9783030867058
024	7		_a10.1007/978-3-030-86705-8 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRA644.C67 _b2022 EB
100	1		_aCascella, Marco _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _999410
245	1	0	_aFeatures and Management of Acute and Chronic Neuro-Covid _cby Marco Cascella, Elvio De Blasio
250			_a1st edition 2022
264		1	_aCham _bSpringer International Publishing _c2022
300			_a1 recurso en línea (XIX, 158 páginas) _b10 ilustraciones, 2 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
505	0		_aIntroduction -- Part I. Pathophysiology of COVID-19-associated neurotoxicity -- An update on preclinical findings -- Ongoing clinical investigations -- Perspectives -- Part II. Clinical manifestations of acute neurotoxicity -- Clinical features -- CNS complications -- PNS complications -- Diagnosis.-Management -- Perspectives -- Part III. Neurological and psychiatric sequelae in COVID-19 survivors.-Clinical features -- Neurological late complications -- psychological and psychiatric sequelae.-Diagnosis -- Tools -- The role of imaging -- Preventive strategies -- Social and economic impact.-Multidisciplinary management -- Perspectives.
520			_aThis book underlines how COVID-19 is a multisystem inflammatory disease and how its pathophysiology can predispose to an increased risk of neurological issues. Several scientific pieces of evidence showes the mechanisms underlying the neuroinvasive capacity of the SARS-CoV-2 through direct viral damage and indirect processes entering the CNS by different routes including the vasculature, the olfactory and trigeminal nerves, the cerebrospinal fluid, and the lymphatic system inducing a direct neurotoxicity. Furthermore, the pro-inflammatory cytokine storm and oxidative stress can induce microglial activation and damage to the blood-brain barrier, culminating in widespread neuroinflammatory process. This acute neurotoxicity is clinically expressed as anosmia and ageusia, headache, nausea and vomiting, but other neurologic manifestations such as acute cerebrovascular diseases, consciousness impairment due to encephalitis, and meningitis are also described. The PNS can also be affected by infectious damage and clinical manifestations including Guillain-Barré syndrome, polyneuritis cranialis, and Miller Fisher Syndrome. A special issue concerns the neurocognitive dysfunction and altered consciousness manifested as delirium, agitation and confusion. Non-specific symptoms such as dizziness, seizures can accompany clinical pictures. Regardless of the admission diagnosis, a high percentage of patients discharged from ICUs develop disabilities affecting physical, cognitive and psychological activities. The symptoms such as asthenia, memory disturbances, depression, sleep disturbances, anxiety, and Post-traumatic stress disorder (PTSD), configure the so-called Post-intensive Care Syndrome (PICS). Multimodal management during the ICU stay and implementation of follow-up programs at patient discharge can reduce the incidence of this syndrome, improving the quality of life of surviving patients. In this complex scenario, a careful clinical approach through reliable diagnostic tools, and epidemiological studies aimed at evaluating the dimensions of the problem also in economic terms, is urgently needed. This book represents a valuable aid for all those healthcare professionals (intensivists, neurologist and psychiatrists, as well) involved in the management of these critically ill patients.
988			_aSpringer_Medicine_2022
650		7	_2embne _9683668 _aCOVID-19
650		7	_2embne _9159274 _aNeurotoxicología
700	1		_9685969 _aDe Blasio, Elvio _eautor
776	0	8	_iPrinted edition: _z9783030867041
776	0	8	_iPrinted edition: _z9783030867065
776	0	8	_iPrinted edition: _z9783030867072
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-86705-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b01/2023 _dz _eb _zSI