000			04981nam a22003735i 4500
001			394841
003			ES-MaUEC
005			20230102123204.0
007			cr nn 008mamaa
008			220801s2022 sz | s |||| 0|eng d
020			_a9783031049989
024	7		_a10.1007/978-3-031-04998-9 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
100	1		_aWang, Zhiguo _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut
245	1	0	_aPolypharmacology _bPrinciples and Methodologies _cby Zhiguo Wang, Baofeng Yang
250			_a1st edition 2022
264		1	_aCham _bSpringer International Publishing _c2022
300			_a1 recurso en línea (XXV, 856 páginas) _b12 ilustraciones, 9 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
505	0		_aPART I. Polypharmacology as a New Branch of Pharmacology: Concept and Principles -- Basics of Polypharmacology -- Polypharmacology in Clinical Applications: Multitarget Multidrug-combination (MTMD-C) -- Polypharmacology in Clinical Applications: Multitarget Multidrug-single-formulation (MTMD-SF) -- Polypharmacology in Clinical Applications: Multitarget Single-drug (MTSD) -- Polypharmacology in Drug Discovery: Designed Epigenetic MTSD and Small-molecule MTSD -- Anti-cancer Polypharmacology -- Cardiovascular Polypharmacology -- Neuronal Polypharmacology -- Pulmonary Polypharmacology -- Polypharmacology of Metabolic Disease -- Polypharmacology of Infectious Disease -- Polypharmacology of Inflammation -- Anti-psychotics Polypharmacology -- Anti-aging Polypharmacology -- Polypharmacology in Drug Repurposing -- Polypharmacology and Unintended Drug Promiscuity -- Polypharmacology Pharmacokinetics -- The Future of Polypharmacology -- PART II. Polypharmacology in New Drug Development: Strategies and Protocols -- Designed MTSD Discovery Process -- Designed MTSD Discovery Strategies -- Designed MTSD Discovery Technologies -- Designed MTSD Discovery Databases -- Designed MTSD Target Deconvolution.-Designed MTSD Target Validation -- Designed MTSD Lead Identification and Optimization -- Designed MTSD Discovery Protocols -- Natural Products in MTSD Discovery -- Polypharmacology Procedures for Drug Repurposing -- Polypharmacology Procedures for Drug Promiscuity Discovery.
520			_aThere is a growing interest in unmet needs for the development of a new discipline in drug discovery and in university education on Polypharmacology. However, there has not been a book with the comprehensive compilation of basic knowledge and advanced methodology on Polypharmacology. This book aims to meet the needs of making Polypharmacology a new sub-discipline of Pharmacology, not only being a hot area of pharmacological research and education but also a new paradigm for drug discovery. It contains the contents covering the entire scope of Polypharmacology including systemic in-depth exposition of basic knowledge, novel concepts, innovative technologies, and translational and clinical applications by showcasing state-of-the-art strategies and step-by-step instructions of cutting-edge methods. The contents of Polypharmacology targets broad readerships including scientists in pharmacology research and drug development, and university teachers and graduates in medical school or school of pharmacy. Rich in illustrations and tables to showcase readers for better understanding the concepts and technologies related to Polypharmacology; Provides comprehensive, systemic, holistic, and explicit explanations and discussion of the fundamental knowledge, background information, conceptual evolution, and updated methodology, as well as in-depth mechanisms behind the knowledge and methodology of Polypharmacology; Main emphasis on rationally designed Polypharmacology or "multi-target, single-drug (MTD)" pharmacology, which represents the major future direction of Polypharmacology and Pharmacology; Describes the clinical applications of Polypharmacology to various human diseases in the clinical and preclinical settings; Contains a wide collection of the state-of-the-art Polypharmacology technologies applicable to the designed MTD discovery and the step-by-step descriptions of drug discovery process applying Polypharmacology principles and methodologies.
700	1		_aYang, Baofeng _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut
776	0	8	_iPrinted edition: _z9783031049972
776	0	8	_iPrinted edition: _z9783031049996
776	0	8	_iPrinted edition: _z9783031050008
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-031-04998-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
988			_aSpringer_BiomedLife_2022
999			_c394841 _d394841