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008			220709s2022 sz | s |||| 0|eng d
020			_a9783030976415
024	7		_a10.1007/978-3-030-97641-5 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRA1051 _b2022 EB
245	0	0	_aBrain Organoids in Research and Therapy : _bFundamental Ethical and Legal Aspects _cedited by Hans-Georg Dederer, David Hamburger
250			_a1st edition 2022
264		1	_aCham _bSpringer International Publishing, _c2022
300			_a1 recurso en línea (VIII, 271 páginas) _b9 ilustraciones, 7 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aAdvances in Neuroethics _x2522-5685
505	0		_aChapter 1) Introductory Remarks -- Part I) Scientific Background -- Chapter 2) Development of Brain Organoids on the Basis of Genome-Edited iPSC-Derived Brain Cells -- Chapter 3) Cell-Based Therapy and Genome Editing in Parkinson's Disease: Quo Vadis -- Part II) The Status Debate -- Chapter 4) Human Cerebral Organoids: Evolving Entities and Their Moral Status -- Chapter 5). Legal perspective: What is, or Should Be, the Legal Status of Brain Organoids? -- Part III) The Informed Consent Challenge -- Chapter 6) Ethical Perspective: Ethics Considerations Regarding Donors' and Patients' Consent -- Chapter 7) The Legal Perspective: The Legal Requirements for-and Limits to-the Donor's and the Patient's Consent -- Part IV) The Chimera Issue -- Chapter 8) Moral Permissibility of Transplantation of Human Brain Organoids into Animals -- Chapter 9) Transplantation of Human Brain Organoids into Animals - The Legal Issues -- Part V) The Enhancement Conundrum -- Chapter 10) Building a Better Beast: Enhancing the Minds of Animals -- Chapter 11) Legal Arguments in Favour of and Against Neuroenhancement by Means of Brain Organoids -- Part VI) The Harmonization Problem -- Chapter 12) Legal Perspective: A Global Harmonisation of Legal Standards for Brain Organoid Research and Therapy?. .
520			_aThis volume elucidates the pivotal ethical and legal issues arising from the use of brain organoids for research, therapeutic and enhancement purposes. The function of the human brain is still a mystery. Until recently, only post-mortem tissue was available for a structural examination of the brain. Consequently, the examination results could only reflect the state at the end of life. However, in order to better understand the development and function of the human brain, dynamic and functional investigations of different human brain cells are necessary. This is where brain organoids, artificially grown in vitro miniature brains, provide the opportunity for more flexible research scenarios. At the same time, however, the use of brain organoids in research and therapy raises the question of how these new entities are to be treated from an ethical and legal point of view. Against this background, this volume aims at clarifying the normative implications of the use of brain organoids in research and therapy. The ethical reflections on the status of brain organoids, informed consent, human-to-animal chimeras and neuro-enhancement are mirrored by corresponding legal analyses. The ethical and legal assessments are preceded by an introduction to the scientific and medical background of the brain organoid technology. A final chapter will be devoted to the issue of whether international harmonization of normative standards for brain organoid research and therapy is feasible and advisable.
988			_aSpringer_Medicine_2022
650		7	_2embne _9138379 _aMedicina legal
700	1		_aDederer, Hans-Georg _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aHamburger, David _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9783030976408
776	0	8	_iPrinted edition: _z9783030976422
776	0	8	_iPrinted edition: _z9783030976439
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-97641-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b12/2022 _dz _eh _zSI