000			03637nam a22003615i 4500
001			394637
003			ES-MaUEC
005			20230102123144.0
007			cr nn 008mamaa
008			221216s2022 sz | s |||| 0|eng d
020			_a9783031208485
024	7		_a10.1007/978-3-031-20848-5 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
100	1		_aSchatten, Heide _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut
245	1	4	_aThe Centrosome and its Functions and Dysfunctions _cby Heide Schatten
250			_a1st edition 2022
264		1	_aCham _bSpringer International Publishing _c2022
300			_a1 recurso en línea (VII, 111 páginas) _b18 ilustraciones, 17 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aAdvances in Anatomy Embryology and Cell Biology _x2192-7065 _v235
505	0		_aCell and Molecular Biology of Centrosome Structure and Function -- The centrosome Cycle within the cell cycle -- Centrosome as center for proteolytic activity and dysfunctions associated with pathogenesis of human disease -- Centrosome dysfunctions in cancer -- Virus exploitation of centrosomes -- Centrosomes in reproduction -- Transition from centrosomal to non-centrosomal microtubule organization during cellular polarization -- External and environmental effects on Centrosomes -- Centrosomes and centrosome equivalents in other systems -- Non-centrosomal microtubule organization in plant cells.
520			_aThe book provides a comprehensive overview of classic and modern approaches of centrosome research, including new aspects of centrosome functions focusing on primary cilia and their implications in numerous diseases. In addition, several chapters raise awareness of centrosomes in areas that have not yet fully considered the centrosome as an organelle that impacts other organelle functions directly or indirectly. It further relates centrosome functions to other research areas such as aging and stem cell research. Since its discovery almost 150 years ago the centrosome is increasingly being recognized as a most impactful organelle for its role, not only as primary microtubule organizing center (MTOC) but also as a major communication center for signal transduction pathways and as a center for proteolytic activities. Its significance for cell cycle regulation has been well studied and we now also know that centrosome dysfunctions are implicated in numerous diseases and disorders including cancer, cystic diseases of the kidney, liver fibrosis, cardiac defects, obesity and several other diseases and disorders. This new volume reviews the latest advances in the field and provides valuable background information that is readily understandable for the newcomer and the experienced centrosome researcher alike. Due to the interdisciplinary of the subject, it is a valuable resource for researchers and clinicians working in biomedical research, cell biology, cancer biology, reproduction and developmental biology, neuroscience and stem cell research. .
776	0	8	_iPrinted edition: _z9783031208478
776	0	8	_iPrinted edition: _z9783031208492
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-031-20848-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
988			_aSpringer_BiomedLife_2022
999			_c394637 _d394637