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001			394564
003			ES-MaUEC
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008			220627s2022 si | s |||| 0|eng d
020			_a9789811929168
024	7		_a10.1007/978-981-19-2916-8 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
100	1		_aHonda, Hisao _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut
245	1	0	_aMathematical Models of Cell-Based Morphogenesis _bPassive and Active Remodeling _cby Hisao Honda, Tatsuzo Nagai
250			_a1st edition 2022
264		1	_aSingapore _bSpringer International Publishing _c2022
300			_a1 recurso en línea (VIII, 192 páginas) _b1 illus
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aTheoretical Biology _x2522-0446
505	0		_aChapter 1. Introduction -- Chapter 2.Cell center model -- Chapter 3.Applications of the cell center model -- Chapter 4. Vertex mode -- Chapter 5.Applications of the cell models to 2D cell patterns -- Chapter 6.3D vertex model -- Chapter 7.The world of epithelial sheets[7·1] -- Chapter 8.Cells themselves produce force for active remodeling -- Chapter 9.Expansion of shape-dimension -- Chapter 10.Mathematical cell models and morphogenesis.
520			_aThis book describes the shape formation of living organisms using mathematical models. Genes are deeply related to the shape of living organisms, and elucidation of a pathway of shape formation from genes is one of the fundamental problems in biology. Mathematical cell models are indispensable tools to elucidate this problem. The book introduces two mathematical cell models, the cell center model and the vertex model, with their applications. The cell center model is applied to elucidate the formation of neat cell arrangements in epidermis, cell patterns consisting of heterogeneous-sized cells, capillary networks, and the branching patterns of blood vessels. The vertex model is applied to elucidate the wound healing mechanisms of the epithelium and ordered pattern formation involving apoptosis. Pattern formation with differential cell adhesion is also described. The vertex model is then extended from a two-dimensional (2D) to a three-dimensional (3D) model. A cell aggregate involving a large cavity is described to explain the development of the mammalian blastocyst or the formation of an epithelial vesicle. Epithelial tissues and the polarity formation process of the epithelium are also explained. The vertex model also recapitulates active remodeling of tissues and describes the twisting of tissue that contributes to understanding the cardiac loop formation of the embryonic tube. The book showcases that mathematical cell models are indispensable tools to understand the shape formation of living organisms. Successful contribution of the mathematical cell models means that the remodeling of collective cells is self-construction. Examining the successive iterations of self-constructions leads to understanding the remarkable and mysterious morphogenesis that occurs during the development of living organisms. The intended readers of this book are not only theoretical or mathematical biologists, but also experimental and general biologists, including undergraduate and postgraduate students who are interested in the relationship between genes and morphogenesis. .
700	1		_aNagai, Tatsuzo _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut
776	0	8	_iPrinted edition: _z9789811929151
776	0	8	_iPrinted edition: _z9789811929175
776	0	8	_iPrinted edition: _z9789811929182
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-19-2916-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
988			_aSpringer_BiomedLife_2022
999			_c394564 _d394564