000			03836nam a22003615i 4500
001			394551
003			ES-MaUEC
005			20230102123140.0
007			cr nn 008mamaa
008			221208s2022 si | s |||| 0|eng d
020			_a9789811971228
024	7		_a10.1007/978-981-19-7122-8 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
100	1		_aGao, Yuansheng _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut
245	1	0	_aBiology of Vascular Smooth Muscle _bVasoconstriction and Dilatation _cby Yuansheng Gao
250			_a2nd edition 2022
264		1	_aSingapore _bSpringer International Publishing _c2022
300			_a1 recurso en línea (XV, 424 páginas) _b1 illus
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
505	0		_aArchitecture of the vessel wall -- Ultrastructure of vascular smooth muscle -- Vascular endothelium -- Electrical and mechanical properties of vascular smooth muscle -- Biochemistry of the contractile proteins of smooth muscle -- Metabolism of vascular smooth muscle -- Neurotransmitters -- Endothelium-derived factors -- Local metabolic factors -- Shear stress, myogenic response, and blood flow autoregulation -- Intracellular Ca2+ regulation -- Regulation of myosin light chain phosphorylation -- Cyclic AMP signaling -- Cyclic GMP signaling -- MicroRNAs and vasoreactivity -- Extracellular vesicles as unique signaling messengers -- Genetic and epigenetic modification -- Coronary vasoreactivity -- Cerebral vasoreactivity -- Pulmonary vasoreactivity -- Renal vasoreactivity -- Hypoxic vasoreactivity -- Ageing and vasoreactivity.
520			_aThis book provides a concise yet comprehensive review of the morphological, biochemical, electrical, mechanical, and metabolic properties of vascular smooth muscle, the regulation of vascular activities and the intracellular signaling involved. It particularly focuses on newly identified vasoactive agents, enzymes and transduction mechanisms. It also discusses the latest findings in the regulation of cerebral, coronary and pulmonary circulation as well as vascular activity under hypoxia and ageing. The second edition intends to update the contents of the first edition with the latest achievements in the regulation of vascular activities from biochemical, structural, genetic, physiological, and pharmacological aspects. In addition, two new chapters related to microRNA and extracellular vesicles have been added to reflect their newly discovered important roles in vascular activities. The contraction and dilatation activities of vasculature are of fundamental importance for maintaining circulation homeostasis and adapting to physiological changes. Over the last four decades, there have been significant advances in our understanding of the biochemical, structural, genetic, physiological, and pharmacological aspects of vascular activity regulation, and these insights into the responsiveness of blood vessels under normal and pathophysiological conditions help to provide valuable weapons in the fight vascular diseases. The book is of interest to researchers and graduate students, both in basic research and in clinic settings, in the field of vascular biology.
776	0	8	_iPrinted edition: _z9789811971211
776	0	8	_iPrinted edition: _z9789811971235
776	0	8	_iPrinted edition: _z9789811971242
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-19-7122-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
988			_aSpringer_BiomedLife_2022
999			_c394551 _d394551