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008			221114s2022 sz a s |||| 0|eng d
020			_a9783031101311
024	7		_a10.1007/978-3-031-10131-1 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC647.H9 _b2022 EB
245	0	0	_aParaproteinemia and Related Disorders _cedited by Gaafar Ragab, Luca Quartuccio, Hadi Goubran
250			_a1st edition 2022
264		1	_aCham _bSpringer International Publishing _c2022
300			_a1 recurso en línea (XVI, 397 páginas) _b42 ilustraciones, 40 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
505	0		_aThe phenomenon of Paraproteinemia -- B Cell in Health and Disease -- Immunoglobulins, structure and function -- The Bone marrow as a hotbed for Plasma Cell activation -- Animal Models in Monoclonal Immunoglobulin Related Diseases -- An Approach to The Diagnosis of Paraproteinemia -- Amyloidosis: Pathogenesis, types and diagnosis -- Amyloidosis: Clinical Manifestations and Treatment -- Primary Light Chain (AL) Amyloidosis -- Monoclonal Immunoglobulin Deposition Disease -- Multiple Myeloma -- Monoclonal Gammopathy of Undetermined Significance (MGUS) & Highlight on Monoclonal Gammopathy of Neurological Significance (MGNS) -- Monoclonal Gammopathy of Renal Significance: An Insight -- Waldenström Macroglobulinemia -- IgG4 Related Disease Overview: Pathology, Clinical picture and Treatment -- Type I cryoglobulinemia -- Paraproteinemias associated with Autoimmune Diseases -- Infections and Paraproteinemia -- Paraproteinemia In Autoinflammatory Diseases -- Paraproteins associated with malignancy -- Monoclonal Gammopathies with Miscellaneous Associations -- Novel and Experimental Clone-directed Therapies -- Non-Pharmacological Management of Paraproteinemia.
520			_aThis book presents paraproteinemia and the highly complex scientific information behind it to clinicians in a way they can understand and, ultimately, apply to their diagnostic and treatment practices. Paraproteinemia or dysproteinemia is characterized by the overproduction of an immunoglobulin by clonal expansion of cells from the B cells lineage which includes the plasma cells. The resultant monoclonal protein can be composed of the entire immunoglobulin or of its components. The identification and categorization of the different representatives of this group of disorders have traveled a long distance, but despite its high prevalence there is surprisingly limited evidence, in some areas, to guide the best clinical practice both at the time of diagnosis and during follow up. This book seeks to fill that gap. The book is divided into three sections, introductory chapters, disease entities and experimental therapies. The text guides clinicians through these diseases and disorders. The group of renal diseases attributed to deposition of monoclonal immunoglobulins or their components are arranged as one disease category in order to simplify the understanding of these complicated diseases in plasma cell dysplasia. In emulation of this practical approach, at a larger scale, the volume editors and chapter authors attempt to encompass the whole spectrum of the paraproteinemias in this text. This will have the dual benefit of offering the audience a panoramic view of this group of disorders and simultaneously keeping them focused on its individual representatives. There have been many recent advances in diagnosis, risk stratifications, and management of many members of this group of diseases and they are explored in depth here. This is an ideal guide for rheumatologists, hematologists, nephrologists, immunologists, oncologists, and relevant trainees caring for patients with paraproteinemia and related disorders.
988			_aSpringer_Medicine_2022
650		7	_2embne _9685835 _aGammapatías monoclonales
650		7	_2embne _9145189 _aAmiloidosis
650		7	_2embne _9160182 _aMieloma múltiple
700	1		_aRagab, Gaafar _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aQuartuccio, Luca _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aGoubran, Hadi _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9783031101304
776	0	8	_iPrinted edition: _z9783031101328
776	0	8	_iPrinted edition: _z9783031101335
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-031-10131-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b12/2022 _dz _esc _zSI