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008			220910s2022 si | s |||| 0|eng d
020			_a9789811923203
024	7		_a10.1007/978-981-19-2320-3 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
100	1		_aSpasov, Alexander A _eautor _0(orcid)0000-0002-7185-4826 _1https://orcid.org/0000-0002-7185-4826 _4aut _4http://id.loc.gov/vocabulary/relators/aut
245	1	0	_aPharmacology of Drug Stereoisomers _cby Alexander A Spasov, Igor N Iezhitsa, Pavel M Vassiliev, Alexander A Ozerov, Renu Agarwal
250			_a1st edition 2022
264		1	_aSingapore _bSpringer International Publishing _c2022
300			_a1 recurso en línea (XI, 207 páginas) _b174 ilustraciones, 6 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aProgress in Drug Research _x2297-4555 _v76
505	0		_aPreface -- General principles of chirality -- Quantitative methods of analysing chirality drugs - Chirality and pharmacokinetics -- Drugs regulating the function of peripheral nervous system -- In silico search for chiral drug compounds.
520			_aThe book is devoted to an important aspect of pharmacology and pharmaceutical chemistry, i.e. the significance of stereoisomerism of drugs for their biological effect from the point of view of their pharmacokinetics, pharmacodynamics and toxicology. The authors review the landmarks in the development of stereochemistry and stereopharmacology. Present-day IUPAC terminology is discussed; general issues of stereoisomerism are considered including separation of racemic mixtures and asymmetric synthesis of isomers, methods of quantifying the isomers of a drug in biological material. The authors put special emphasis on general problems of the influence of stereoisomerism on pharmacological and adverse effects of drugs. A classification of drugs based on stereochemical properties of their isomers is proposed. Possibilities of interaction of stereoisomers in racemic mixtures are discussed. A considerable portion of the book is devoted to pharmacological action of the main groups of drugs whose structure includes asymmetric atoms (that is, drugs with several isomers). Detailed attention is paid to advisability of developing single isomer drugs and to the specifics of their study at the stage of preclinical and clinical trials.
700	1		_aIezhitsa, Igor N _eautor _0(orcid)0000-0002-2852-8486 _1https://orcid.org/0000-0002-2852-8486 _4aut _4http://id.loc.gov/vocabulary/relators/aut
700	1		_aVassiliev, Pavel M _eautor _0(orcid)0000-0002-8188-5052 _1https://orcid.org/0000-0002-8188-5052 _4aut _4http://id.loc.gov/vocabulary/relators/aut
700	1		_aOzerov, Alexander A _eautor _0(orcid)0000-0002-4721-0959 _1https://orcid.org/0000-0002-4721-0959 _4aut _4http://id.loc.gov/vocabulary/relators/aut
700	1		_aAgarwal, Renu _eautor _0(orcid)0000-0002-3050-7449 _1https://orcid.org/0000-0002-3050-7449 _4aut _4http://id.loc.gov/vocabulary/relators/aut
776	0	8	_iPrinted edition: _z9789811923197
776	0	8	_iPrinted edition: _z9789811923210
776	0	8	_iPrinted edition: _z9789811923227
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-19-2320-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
988			_aSpringer_BiomedLife_2022
999			_c393941 _d393941