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020 _a9783031071676
024 7 _a10.1007/978-3-031-07167-6
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
245 1 0 _aVertebrate Motoneurons
_cedited by Michael J O'Donovan, Mélanie Falgairolle
250 _a1st edition 2022
264 1 _aCham
_bSpringer International Publishing
_c2022
300 _a1 recurso en línea (XII, 400 páginas)
_b81 ilustraciones, 64 ilustraciones a color
336 _atexto
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
490 0 _aAdvances in Neurobiology
_x2190-5223
_v28
505 0 _aEstablishing the molecular and functional diversity of spinal motoneurons -- Chloride homeostasis in developing motoneurons -- Normal development and pathology of motoneurons: anatomy, electrophysiological properties, firing patterns and circuit connectivity -- Homeostatic regulation of motoneuron properties in development -- Homeostatic plasticity of the mammalian neuromuscular junction -- Diversity of mammalian motoneurons and motor units -- Synaptic projections of motoneurons within the spinal cord -- Recruitment of motoneurons -- Electrical properties of adult mammalian motoneurons.-The cellular basis for the generation of firing patterns in human motor units -- Motoneuronal regulation of central pattern generator and network function -- Extraocular motoneurons and neurotrophism -- Motoneuron diseases -- Electrical and morphological properties of developing motoneurons in postnatal mice and early abnormalities in sod1 transgenic mice -- From physiological properties to selective vulnerability of motor units in amyotrophic lateral sclerosis. .
520 _aThis book aims to provide a comprehensive and timely review of new findings in motoneuron research. Recent findings have revealed that motoneurons are more complex and have more extensive functions than previously imagined. Some of the molecular and genetic pathways that orchestrate the development of motoneurons have been discovered, as have the mechanisms responsible for the selective innervation of muscles by specific pools of motoneurons. These novel findings are revolutionizing ideas about the function of motoneurons and have important implications for motoneuron disease. Chapters from several of the foremost figures in the field are included in this book and will emphasize how basic science is the engine driving the discovery of novel treatments for degenerative motoneuron diseases. Cutting edge developments in the use of pluripotent stem cells to correct motoneuron disease will be also be covered. This book would be useful to students of basic motoneuron physiology, locomotor behavior and motor control. This book would also be of interest to professional neuroscientists, neurologists, and neurosurgeons.
700 1 _aO'Donovan, Michael J
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aFalgairolle, Mélanie
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
776 0 8 _iPrinted edition:
_z9783031071669
776 0 8 _iPrinted edition:
_z9783031071683
776 0 8 _iPrinted edition:
_z9783031071690
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-031-07167-6
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942 _2lcc
_cLE
988 _aSpringer_BiomedLife_2022
999 _c393913
_d393913