000			03328nam a22003975i 4500
001			393878
003			ES-MaUEC
005			20230102123034.0
007			cr nn 008mamaa
008			220901s2022 sz | s |||| 0|eng d
020			_a9783031059148
024	7		_a10.1007/978-3-031-05914-8 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aAlgorithms and Methods in Structural Bioinformatics _cedited by Nurit Haspel, Filip Jagodzinski, Kevin Molloy
250			_a1st edition 2022
264		1	_aCham _bSpringer International Publishing _c2022
300			_a1 recurso en línea (IX, 114 páginas) _b51 ilustraciones, 37 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aComputational Biology _x2662-2432
505	0		_a1. Protein-Ligand Binding with Applications in Molecular Docking -- 2. Explaining Small Molecule Binding Specificity with Volumetric Representations of Protein Binding Sites -- 3. Machine Learning-based Approaches for Protein Conformational Exploration -- 4. Low Rank Approximation Methods for identifying Impactful Pairwise Protein Mutations -- 5. Detection and analysis of amino acid insertions and deletions -- 6. DeepTracerWeb Service for Fast and Accurate De Novo Protein Complex Structure Prediction from Cryo-EM.
520			_aThe three-dimensional structure and function of molecules present many challenges and opportunities for developing an understanding of biological systems. With the increasing availability of molecular structures and the advancing accuracy of structure predictions and molecular simulations, the space for algorithmic advancement on many analytical and predictive problems is both broad and deep. To support this field, a rich set of methods and algorithms are available, addressing a variety of important problems such as protein-protein interactions, the effect of mutations on protein structure and function, and protein structure determination. Despite recent advancements in the field, in particular in protein folding with the development of AlphaFold, many problems still remain unsolved. In this book we focus on a number of topics in Structural Bioinformatics: Cryo-EM structural detection, protein conformational exploration, elucidation of molecular binding surface using geometry, the effect of mutations, insertions and deletions on protein structural stability, and protein-ligand binding.
700	1		_aHaspel, Nurit _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aJagodzinski, Filip _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aMolloy, Kevin _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9783031059131
776	0	8	_iPrinted edition: _z9783031059155
776	0	8	_iPrinted edition: _z9783031059162
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-031-05914-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
988			_aSpringer_Computer_2022
999			_c393878 _d393878