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020 _a9781493909568
024 7 _a10.1007/978-1-4939-0956-8
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
_dES-MaUEC
050 4 _aRM301.3 .G45
_b2014 EB
245 0 0 _aPharmacogenomics in Drug Discovery and Development
_cedited by Qing Yan
250 _a2nd edition 2014
264 1 _aNew York, NY
_bSpringer International Publishing
_c2014
300 _a1 recurso en línea (XIII, 715 páginas)
_b44 ilustraciones, 32 ilustraciones a color
336 _atexto
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
490 0 _aMethods in Molecular Biology
_x1940-6029
_v1175
505 0 _aFrom Pharmacogenomics and Systems Biology to Personalized Care: A Framework of Systems and Dynamical Medicine -- Translational Bioinformatics Approaches for Systems and Dynamical Medicine -- Whole Blood Transcriptomic Analysis to Identify Clinical Biomarkers of Drug Response -- Diagnostic Procedures for Paraffin Embedded Tissues Analysis in Pharmacogenomic Studies -- Approach to Clinical and Genetic Characterization of Statin-Induced Myopathy -- Pharmacogenetics of Membrane Transporters: A Review of Current Approaches -- G Protein-Coupled Receptor Accessory Proteins and Signaling: Pharmacogenomic Insights -- G Protein-Coupled Receptor Mutations and Human Genetic Disease -- Pharmacogenetics of the G Protein-Coupled Receptors -- Pharmacogenomics of Heart Failure -- Pharmacogenomics in the Development and Characterization of Atheroprotective Drugs -- Management of Side-Effects in the Personalized Medicine Era: Chemotherapy Induced Peripheral Neuropathy -- Pharmacogenomics of Alzheimer's Disease: Novel Therapeutic Strategies for Drug Development -- Pharmacogenetics of Antipsychotic Treatment in Schizophrenia -- Pharmacogenetics of Addiction Therapy -- Pharmacogenetics in Rheumatoid Arthritis -- The Pharmacogenomics of Osteoporotic Fractures -- Pharmacogenomics and Pharmacoepigenomics in Pediatric Medicine -- Pharmacogenomics in Children.
520 _aCovering topics from individual molecules to systemic diseases, from basic concepts to advanced technologies, Pharmacogenomics in Drug Discovery and Development , Second Edition provides a practical, state-of-the-art and integrative view of the application of pharmacogenomics in drug discovery and development. A wide range of theoretical and experimental approaches are introduced to meet the problem-solving objectives for understanding the complexity in health and diseases, from laboratory tests to computational analysis. The development of pharmacogenomics represents the evolution of biomedicine from treating the disease itself to treating the malfunction of an individual person, the "root" of diseases. With the change of focus from disease-centered to human-centric medicine, pharmacogenomics brings hope for the transformation from simple disease treatment to accurate prediction and effective prevention. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.   Authoritative and easily accessible, Pharmacogenomics in Drug Discovery and Development, Second Edition seeks to serve both professionals and novices with comprehensive resources and a holistic view for the translation of pharmacogenomics into better preventive and personalized medical care.
988 _aSpringer_Protocols_2014
650 7 _2embne
_9165192
_aFarmacogenómica
776 0 8 _iPrinted edition:
_z9781493909575
776 0 8 _iPrinted edition:
_z9781493909551
776 0 8 _iPrinted edition:
_z9781493947584
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-4939-0956-8
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942 _2lcc
_cLE
998 _b12/2023
_dz
_eb
_zSI