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008			100301s2003 xxua o |||| 0|eng d
020			_a9781592593286
024	7		_a10.1385/1592593283 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC268.4 _b2003 EB
245	0	0	_aTumor Suppressor Genes _nVolume 1, _pPathways and Isolation Strategies _cedited by Wafik S. El-Deiry
250			_a1st edition 2003
264		1	_aTotowa, NJ _bHumana Press _c2003
300			_a1 recurso en línea (520 páginas) _b73 ilustraciones
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v222
505	0		_aKnown Tumor Suppessor Genes and Pathways -- Growth Control by the Retinoblastoma Gene Family -- The APC Tumor Suppressor Pathway -- Hereditary Breast and Ovarian Cancer Genes -- Hereditary Colon Cancer Genes -- Patched, Hedgehog, and Skin Cancer -- Tumor Suppressor Genes in Lung Cancer -- TP53, hChk2, and the Li-Fraumeni Syndrome -- Genetic Alterations in Esophageal Cancer -- PTEN and Cancer -- VHL and Kidney Cancer -- p16INK4A and Familial Melanoma -- The INK4a/ARF Locus and Human Cancer -- Progression Model of Prostate Cancer -- Neurofibromatosis Type 1 -- Wilms' Tumor as a Model for Cancer Biology -- Inadequate "Caretaker" Gene Function and Human Cancer Development -- The Regulation of Tumor Suppressor Genes by Oncogenes -- Identification of Tumor Suppressor Genes -- Determination of Cancer Allelotype -- Epidemiological Approaches to the Identification of Cancer Predisposition Genes -- Characterization of Translocations in Human Cancer -- Positional Approaches to Cancer Genetics -- Hybrid Capture of Putative Tumor Suppressor Genes -- Approaches to Proteomic Analysis of Human Tumors -- Representational Difference Analysis of Gene Expression -- Antisense Libraries to Isolate Tumor Suppressor Genes -- Genetic Suppressor Elements in the Characterization and Identification of Tumor Suppressor Genes -- Cross-linking Subtractive Hybridization to Identify Tumor Suppressor Genes -- Suppression Subtractive Hybridization for Identification and Functional Analysis of Tumor Suppressor Genes -- SAGE as a Strategy to Isolate Cancer-Related Genes -- Differential Display Techniques to Identify Tumor Suppressor Gene Pathways -- Detection of Mismatch Repair Gene Expression in Urologic Malignancies.
520			_aPowerful new tools are now available to discover and understand tumor suppressor genes (TSGs) and the biochemical mechanisms by which they control cancer development and progression. In Tumor Suppressor Genes, Volume 1: Pathways and Isolation Strategies, leading physician scientists and academic researchers review all the known tumor suppressor genes, explain how they work, and describe how they were discovered and isolated. In many cases, the authors discuss specific genes that are frequently involved in hereditary or sporadic cancers. They also provide a detailed guide to using powerful molecular genetic, cytogenetic, proteomic, and cell biological strategies to isolate and characterize novel tumor suppressor genes and their targets. The companion volume of this set, Tumor Suppressor Genes, Volume 2: Regulation, Function, and Medicinal Applications, demonstrates how best to explore the cell biology and biochemical function of such genes, and their encoded proteins, to study their physiological role in vivo, and to use information on TSGs to develop diagnostic and therapeutic strategies for cancer. Comprehensive and authoritative, the two volumes of Tumor Suppressor Genes provide an unparalleled compilation of key data on all known tumor suppressor pathways and a treasury of techniques for their discovery, analysis, and uses in cancer therapeutics.
988			_aSpringer_Protocols_2003
650		7	_2embne _9273952 _aCáncer _xAspectos genéticos
776	0	8	_iPrinted edition: _z9780896039865
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1385/1592593283 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b12/2023 _dz _eb _zSI