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008			100427s2010 xxua o |||| 0|eng d
020			_a9781607617006
024	7		_a10.1007/978-1-60761-700-6 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRM301.55 _b2010 EB
245	0	0	_aMembrane Transporters in Drug Discovery and Development : _bMethods and Protocols _cedited by Qing Yan
250			_a1st edition 2010
264		1	_aTotowa, NJ _bHumana Press _c2010
300			_a1 recurso en línea (XIII, 357 páginas) _b60 ilustraciones, 2 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v637
505	0		_aMembrane Transporters and Drug Development: Relevance to Pharmacogenomics, Nutrigenomics, Epigenetics, and Systems Biology -- Bioinformatics for Transporter Pharmacogenomics and Systems Biology: Data Integration and Modeling with UML -- Multidrug Resistance: Phylogenetic Characterization of Superfamilies of Secondary Carriers that Include Drug Exporters -- Targeting Drug Transporters - Combining In Silico and In Vitro Approaches to Predict In Vivo -- Methods to Evaluate Transporter Activity in Cancer -- Analysis of Expression of Drug Resistance-Linked ABC Transporters in Cancer Cells by Quantitative RT-PCR -- Fluorescence Studies of Drug Binding and Translocation by Membrane Transporters -- A Model for Transport Studies of the Blood-Brain Barrier -- Genetic Variants in the Vesicular Monoamine Transporter 1 (VMAT1/SLC18A1) and Neuropsychiatric Disorders -- Equilibrium Binding and Transport by Vesicular Acetylcholine Transporter -- ABC Transporters in Ophthalmic Disease -- Imaging of Protein Translocation In Situ in Skeletal Muscle of Living Mice -- Glucose Transporters in Parasitic Protozoa -- NMR Studies of Membrane Proteins -- Site-Directed Mutagenesis in the Study of Membrane Transporters -- Xenopus laevis Oocytes -- Measurement of Intracellular pH -- Measurement of Plasma Membrane Calcium-Calmodulin-Dependent ATPase (PMCA) Activity -- Assessment of the Contribution of the Plasma Membrane Calcium ATPase, PMCA, Calcium Transporter to Synapse Function Using Patch Clamp Electrophysiology and Fast Calcium Imaging.
520			_aStudies of membrane transporters have had a great impact on our understanding of human diseases and the design of effective drugs. In Membrane Transporters in Drug Discovery and Development: Methods and Protocols, expert researchers provide practical methodologies of the ongoing research on membrane transporters, considering applications of transporter technologies in drug discovery and development. Chapters include new and useful fields and methodologies, including pharmacogenomics, nutrigenomics, systems biology, bioinformatics, nuclear magnetic resonance (NMR), imaging, and quantitative real-time-PCR. Transporter studies in drug discovery and development for various diseases are discussed, including neuropsychiatric disorders, cardiovascular diseases, ophthalmic diseases, cancer, and diabetes. Composed in the highly successful Methods in Molecular Biology™ series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Wide-ranging and current, Membrane Transporters in Drug Discovery and Development: Methods and Protocols delivers a collection of practical protocols that can be used immediately in the lab, along with critical surveys of key topics by leading researchers in the field.
988			_aSpringer_Protocols_2010
650		7	_2embne _9137892 _aMedicamentos _xMetabolismo _vManuales de laboratorio
776	0	8	_iPrinted edition: _z9781607617150
776	0	8	_iPrinted edition: _z9781607616993
776	0	8	_iPrinted edition: _z9781493957330
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-60761-700-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b12/2023 _dz _eb _zSI