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008			100301s2006 xxua o |||| 0|eng d
020			_a9781597451161
024	7		_a10.1385/1597451169 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aTP248.65 .P76 _b2006 EB
245	0	0	_aProtein Design _cedited by Raphael Guerois, Manuela López de la Paz
250			_a1st edition 2006
264		1	_aTotowa, NJ _bHumana Press _c2006
300			_a1 recurso en línea (XIV, 300 páginas) _b65 ilustraciones
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v340
505	0		_aDesign of Structural Elementary Motifs -- Structure and Stability of the ?-Helix -- De novo Design of Monomeric ?-Hairpin and ?-Sheet Peptides -- De novo Proteins From Binary-Patterned Combinatorial Libraries -- Non-Protein Amino Acids in the Design of Secondary Structure Scaffolds -- Design and Synthesis of ?-Peptides With Biological Activity -- Design Of Entire Proteins And Protein Complexes -- Design of Miniproteins by the Transfer of Active Sites Onto Small-Size Scaffolds -- Consensus Design as a Tool for Engineering Repeat Proteins -- Multiple Sequence Alignment as a Guideline for Protein Engineering Strategies -- Sequence Search Methods and Scoring Functions for the Design of Protein Structures -- Prediction of Protein-Protein Interaction Based on Structure -- Electrostatic Design of Protein-Protein Association Rates -- Design of Amyloidogenic Polypeptides and Amyloid Inhibitors -- Peptide Model Systems for Amyloid Fiber Formation Design Strategies and Validation Methods -- Protein Misfolding Disorders and Rational Design of Antimisfolding Agents.
520			_aRecent major advances in our understanding of modulating protein functions has led to the development of new methods and algorithms to predict and decipher how amino acid sequences shape three-dimensional structures. Protein Design: Methods and Applications presents the most up-to-date protein design and engineering strategies so that readers can undertake their own projects with a maximum chance of success. The authors present integrated computational approaches that require various degrees of computational complexity, and the major accomplishments that have been achieved in the design and structural characterization of helical peptides and proteins. Other topics of discussion include: design of structural elementary motifs, entire proteins, and interfaces of protein complexes, and of amyloidogenic polypeptides and amyloid inhibitors. Authoritative and cutting-edge, Protein Design: Methods and Applications will be of major interest to protein scientists, biochemists, and all experimentalists selecting the strategy most adaptable for their design problem.
988			_aSpringer_Protocols_2006
650		7	_2embne _9139861 _aProteínas _xBiotecnología
776	0	8	_iPrinted edition: _z9781617376597
776	0	8	_iPrinted edition: _z9781588295859
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1385/1597451169 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b12/2023 _dz _eb _zSI