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008			120814s2012 xxua o |||| 0|eng d
020			_a9781627030687
024	7		_a10.1007/978-1-62703-068-7 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC660 _b2012 EB
245	1	0	_aAnimal Models in Diabetes Research _cedited by Hans-Georg Joost, Hadi Al-Hasani, Annette Schürmann
250			_a1st edition 2012
264		1	_aTotowa, NJ _bHumana Press _c2012
300			_a1 recurso en línea (XI, 325 páginas) _b51 ilustraciones, 26 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v933
505	0		_aThe Non-Obese Diabetic (NOD) Mouse as a Model of Human Type 1 Diabetes -- Assessment of Diabetic Nephropathy in the Akita Mouse -- The BB Rat as a Model of Human Type 1 Diabetes -- Diabetes in Mice with Monogenic Obesity: The db/db Mouse and Its Use in the Study of Cardiac Consequences -- Pathophysiology and Genetics of Obesity and Diabetes in the New Zealand Obese Mouse: A Model of the Human Metabolic Syndrome -- The TALLYHO Mouse as a Model of Human Type 2 Diabetes -- Diet-Induced Diabetes in the Sand Rat (Psammomys obesus) -- Diabetes in Zucker Diabetic Fatty Rat -- The GK Rat: A Prototype for the Study of Non-Overweight Type 2 Diabetes? -- Experimentally Induced Rodent Models of Type 2 Diabetes -- Investigation and Treatment of Type 2 Diabetes in Nonhuman Primates -- Determination of Beta-Cell Function: Insulin Secretion of Isolated Islets -- Determination of Beta-Cell Function: Ion Channel Function in Beta Cells -- Measurement of Glucose Homeostasis  In Vivo: Glucose and Insulin Tolerance Tests -- Measurement of Glucose Homeostasis  In Vivo: Combination of Tracers and Clamp Techniques -- Measurement of Insulin Sensitivity in Skeletal Muscle In Vitro -- Beta-Cell Autoimmunity -- Positional Cloning of Diabetes Genes -- Retinal Digest Preparation: A Method to Study Diabetic Retinopathy -- Lineage Tracing of Pancreatic Stem Cells and Beta Cell Regeneration -- Genetic Lineage Tracing of Beta Cell Neogenesis.
520			_aIn recent years, human studies have made enormous contributions towards an understanding of the genetic basis of diabetes mellitus; however, most of the experimentation needed for the invention and testing of novel therapeutic approaches cannot be performed in humans.  Thus, there is no alternative to appropriate animal models.  In Animal Models in Diabetes Research, expert researchers explore the current status of the most important models and procedures in order to provide a timely resource in experimental diabetology.  The first half of the volume serves as a comprehensive overview on our current knowledge of the pathogenesis and pathophysiology of diabetes in animal models through a series of reviews in model strains.  The book then continues with vital, established protocols that are employed in the characterization and study of animal models of diabetes.  As a volume in the highly successful Methods in Molecular Biology™ series, this work contains the type of detailed description and key implementation advice necessary to achieve successful results.   Authoritative and cutting-edge, Animal Models in Diabetes Research delivers essential content that will be an important resource to advance diabetes research in the years to come.
988			_aSpringer_Protocols_2012
650		7	_2embne _9138582 _aDiabetes _xInvestigación _xModelos animales
776	0	8	_iPrinted edition: _z9781627030694
776	0	8	_iPrinted edition: _z9781627030670
776	0	8	_iPrinted edition: _z9781493962563
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-62703-068-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b12/2023 _dz _eb _zSI