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008			100715s2010 xxu| fo |||| 0|eng d
020			_a9781607614166
024	7		_a10.1007/978-1-60761-416-6 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQR177 _b2010 EB
245	0	0	_aMulti-Drug Resistance in Cancer _cedited by Jun Zhou
250			_a1st edition 2010
264		1	_aTotowa, NJ _bHumana Press _c2010
300			_a1 recurso en línea (XII, 492 páginas) _b67 ilustraciones, 4 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v596
505	0		_aMultidrug Resistance in Cancer -- Multidrug Resistance in Oncology and Beyond: From Imaging of Drug Efflux Pumps to Cellular Drug Targets -- Studying Drug Resistance Using Genetically Engineered Mouse Models for Breast Cancer -- Mechanisms of Multidrug Resistance in Cancer -- Molecular Mechanisms of Drug Resistance in Single-Step and Multi-Step Drug-Selected Cancer Cells -- Pharmacogenetics of ATP-Binding Cassette Transporters and Clinical Implications -- Flow Cytometric Evaluation of Multidrug Resistance Proteins -- Targeted Chemotherapy in Drug-Resistant Tumors, Noninvasive Imaging of P-Glycoprotein-Mediated Functional Transport in Cancer, and Emerging Role of Pgp in Neurodegenerative Diseases -- Epigenetic Regulation of Multidrug Resistance 1 Gene Expression: Profiling CpG Methylation Status Using Bisulphite Sequencing -- Expression and Function of P-Glycoprotein in Normal Tissues: Effect on Pharmacokinetics -- Molecular Mechanism of ATP-Dependent Solute Transport by Multidrug Resistance-Associated Protein 1 -- Impact of Breast Cancer Resistance Protein on Cancer Treatment Outcomes -- Drug Ratio-Dependent Antagonism: A New Category of Multidrug Resistance and Strategies for Its Circumvention -- Reversing Agents for ATP-Binding Cassette Drug Transporters -- Overcoming Multidrug Resistance in Cancer: Clinical Studies of P-Glycoprotein Inhibitors -- Pharmacokinetic and Pharmacodynamic Implications of P-Glycoprotein Modulation -- Examination of CYP3A and P-Glycoprotein-Mediated Drug-Drug Interactions Using Animal Models -- Generating Inhibitors of P-Glycoprotein: Where to, Now? -- Immunosuppressors as Multidrug Resistance Reversal Agents -- Overcoming Multidrug Resistance by RNA Interference -- Circumventing Tumor Resistance to Chemotherapy by Nanotechnology.
520			_aWith the devastating complication of cancer cells becoming simultaneously resistant to many structurally and mechanistically unrelated drugs, the efficacy of chemotherapeutic management of cancer often becomes severely limited. In Multi-Drug Resistance in Cancer, leading researchers in the field provide comprehensive and up-to-date reviews of multidrug resistance mechanisms, from over-expression of ATP-binding cassette drug transporters such as P-glycoprotein, multidrug resistance-associated proteins, and breast cancer resistance protein, to the drug ratio-dependent antagonism and the paradigm of cancer stem cells. The extensive volume also includes strategies to overcome multidrug resistance, from the development of compounds that inhibit drug transporter function to the modulation of transporter expression, as well as techniques for detection and imaging of drug transporters, methods for investigation of drug resistance in animal models, and strategies to evaluate the efficacy of resistance reversal agents. As a volume in the highly successful Methods in Molecular Biology™ series, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and cutting-edge, Multi-Drug Resistance in Cancer offers a state-of-art collection of reviews and methods for both basic and clinician investigators who are interested in the vital study of cancer multi-drug resistance mechanisms and reversal strategies.
988			_aSpringer_Protocols_2010
650		7	_2embne _9139207 _aOncología
776	0	8	_iPrinted edition: _z9781607614173
776	0	8	_iPrinted edition: _z9781607614159
776	0	8	_iPrinted edition: _z9781617796647
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-60761-416-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b01/2024 _dz _ean _zSI