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008			100301s2001 xxu| fo |||| 0|eng d
020			_a9781592591428
024	7		_a10.1385/1592591426 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC382 _b2001 EB
245	0	0	_aParkinson's Disease _b: Methods and Protocols _cedited by M. Maral Mouradian
250			_a1st edition 2001
264		1	_aTotowa, NJ _bHumana Press _c2001
300			_a1 recurso en línea (XI, 317 páginas)
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Medicine _x1940-6037 _v62
505	0		_aGenetics -- Point Mutations in the ?-Synuclein Gene -- Autosomal Recessive Juvenile Parkinsonism (AR-JP): Genetic Diagnosis -- Molecular Pathogenetic Studies -- Parkinson's Disease, Dementia with Lewy Bodies, and Multiple System Atrophy as ?-Synucleinopathies -- ?-Synuclein/Amyloid Interactions -- Functional Defect Conferred by the Parkinson's Disease-Causing ?-Synuclein (Ala30Pro) Mutation -- Molecular Biology of Dopamine-Induced Apoptosis -- Animal Models of Induced Apoptotic Death in the Substantia Nigra -- Apoptotic Morphology in Phenotypically Defined Dopaminergic Neurons of the Substantia Nigra -- The Role of Nitric Oxide in Parkinson's Disease -- Oxidative Stress Indices in Parkinson's Disease -- Molecular Aspects of Basal Ganglia Function -- Quantification of Tyrosine Hydroxylase mRNA -- Immunochemical Analysis of Dopamine Transporters in Parkinson's Disease -- Dopamine Transporter and Vesicular Monoamine Transporter Knockout Mice -- Transcription Mechanisms for Dopamine Receptor Genes -- Detection of DNA/Protein Interactions in Dopamine Receptor Genes -- In Situ Hybridization on Brain Tissue -- Regulation of Striatal N-Methyl-D-Aspartate Receptor (NMDAR) Function by Phosphorylation of its Subunits in Parkinsonian Rats -- Molecular Therapies -- Chronic Intracerebral Delivery of Trophic Factors via a Programmable Pump as a Treatment for Parkinsonism -- Grafting Genetically Engineered Cells into the Striatum of Nonhuman Primates -- Encapsulated Cell Implants as a Novel Treatment for Parkinson's Disease -- Neural Stem Cell Technology as a Novel Treatment for Parkinson's Disease.
520			_aThe use of molecular technologies to study Parkinson's disease in the laboratory is beginning to have a major impact in clinical medicine. In Parkinson's Disease: Methods and Protocols, internationally recognized biomedical investigators describe in detail the major techniques employed in molecular and cellular studies of Parkinson's disease and basal ganglia function, adding along the way considerable background information about the rationale and utility of these methods, as well as about fundamental issues in Parkinson's disease. Widely varied methods are covered, including genetic analyses, molecular pathogenetic investigations of dopaminergic neuronal degeneration, biochemical studies of nigrostriatal neural circuitry, and molecular therapies, such as gene therapy and neural stem cells. Comprehensive and timely, Parkinson's Disease: Methods and Protocols offers scientists and clinicians interested in Parkinson's and related neurodegenerative disorders the major cutting-edge methods-in a readily reproducible format-needed to effectively exploit the potential of cell and molecular biology for elucidating disease mechanisms and for speeding the emergence of novel and more effective therapeutics.
988			_aSpringer_Protocols_2001
650		7	_2embne _9141804 _aParkinson, Enfermedad de
776	0	8	_iPrinted edition: _z9781617371752
776	0	8	_iPrinted edition: _z9781489942289
776	0	8	_iPrinted edition: _z9780896037618
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1385/1592591426 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b01/2024 _dz _ean _zSI