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999			_c393406 _d393406 _x1
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003			ES-MaUEC
005			20240314174355.0
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007			cr nn 008mamaa
008			100301s2007 xxu| fo |||| 0|eng d
020			_a9781603270700
024	7		_a10.1007/978-1-60327-070-0 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQP606 .T44 _b2007 EB
245	0	0	_aTelomerase Inhibition _b: Strategies and Protocols _cedited by Lucy Andrews, Trygve O. Tollefsbol
250			_a1st edition 2007
264		1	_aTotowa, NJ _bHumana Press _c2007
300			_a1 recurso en línea (X, 193 páginas)
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v405
505	0		_aMethods of Telomerase Inhibition -- Telomerase Inhibition by Synthetic Nucleic Acids and Chemosensitization in Human Bladder Cancer Cell Lines -- hTERT Knockdown in Human Embryonic Kidney Cells Using Double-Stranded RNA -- RNA Interference Using a Plasmid Construct Expressing Short-Hairpin RNA -- Retrovirus-Mediated RNA Interference -- Telomerase Inhibition and Telomere Targeting in Hematopoietic Cancer Cell Lines with Small Non-Nucleosidic Synthetic Compounds (BIBR1532) -- Uses of Telomerase Peptides in Anti-Tumor Immune Therapy -- Establishing Cell-Based Reporter Systems for the Analysis of hTERT Expression -- Telomerase RNA Inhibition Using Antisense Oligonucleotide Against Human Telomerase RNA Linked to a 2?,5?-Oligoadenylate -- Knockdown of Telomerase RNA Using Hammerhead Ribozymes and RNA Interference -- Evaluation of Tankyrase Inhibition in Whole Cells -- Inhibition of Telomerase by Targeting MAP Kinase Signaling -- Screening of Telomerase Inhibitors -- Telomerase Inhibition Combined with Other Chemotherapeutic Reagents to Enhance Anti-Cancer Effect.
520			_aDue in part to the selective nature of telomerase inhibition as an anticancer approach, the field has expanded considerably in the past decade. The recent advances in methods of telomerase inhibition encompass many different areas of research including molecular biology, cell biology, biochemistry, oncology and gerontology. Telomerase Inhibition provides methods and protocols for those researchers. The techniques described in this book should provide the researcher with a diverse and comprehensive set of tools with which to study telomerase inhibition. Leaders in the field provide recently developed methods that have widespread application such as targeting the telomerase holoenzyme, its RNA template and other elements associated with telomerase activity. Additional methods involving the screening of telomerase inhibitors and telomerase inhibition combined with other chemotherapeutic agents are presented. This text, on the cutting edge of the field, will provide investigators with the most recent methods applied to the expanding field of telomerase inhibition.
988			_aSpringer_Protocols_2007
650		7	_2embne _9138367 _aQuimioterapia
776	0	8	_iPrinted edition: _z9781617377167
776	0	8	_iPrinted edition: _z9781588296832
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-60327-070-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b01/2024 _dz _ean _zSI