000			03242nam a22003975i 4500
999			_c393365 _d393365
001			393365
003			ES-MaUEC
005			20240210132019.0
006			a||||fo|||| 00| 0
007			cr nn 008mamaa
008			150904s2015 xxu| fo |||| 0|eng d
020			_a9781493929443
024	7		_a10.1007/978-1-4939-2944-3 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQP552 .G16 _b2015 EB
245	0	0	_aDesigner Receptors Exclusively Activated by Designer Drugs _cedited by Gerald Thiel.
250			_a1st edition 2015
264		1	_aNew York, NY _bSpringer International Publishing _c2015
300			_a1 recurso en línea (XVII, 160 páginas) _b28 ilustraciones, 14 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aNeuromethods _x1940-6045 _v108
505	0		_aDefining the Functional Equivalence of Wild Type and Chemically Engineered G Protein-Coupled Receptors -- Design and Analysis of an Arrestin-biased DREADD -- Regulation of Gene Transcription Following Stimulation of Gaq-coupled Designer Receptors -- Chemogenetic Deconstruction of Feeding Circuits -- Dissecting Neuronal Circuits Involved in Olfactory Mediated Behaviors -- The use of DREADDs (Designer Receptors Exclusively Activated by Designer Receptors) in Transgenic Mouse Behavioral Models -- Pharmacogenetic Dissection of Neural Mechanisms Underlying the Regulation of Sleep/Wakefulness using DREADDs -- DREADD'ed addiction: Using Designer Receptors to Delineate Neural Circuits Underlying Drug-Seeking Behaviors -- DREADDs in Drosophila melanogaster.
520			_aThis volume provides current methods to analyze the properties of designer receptors exclusively activated by designer drugs (DREADDs) in vitro and to measure the biological responses of DREADD activation in different neuronal populations in vivo. Chapters focus on the utility of DREADD technology to selectively stimulate or inhibit neuronal activity in selected brain areas of transgenic mice. In addition, the successful use of DREADD expression in rats and Drosophila is described. Together, the DREADD technology represents a non-invasive, chemical-genetic tool for investigating neuronal signaling and the resulting behavioural responses in vivo. Written in the popular Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory. Concise and easy-to-use, Designer Receptors Exclusively Activated by Designer Drugs aims to ensure successful results in the further study of this vital field.
988			_aSpringer_Protocols_2015
650		7	_2embne _9157991 _aDrogas de diseño
776	0	8	_iPrinted edition: _z9781493929436
776	0	8	_iPrinted edition: _z9781493929450
776	0	8	_iPrinted edition: _z9781493949571
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-4939-2944-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b12/2023 _dz _ean _zSI