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020 _a9781607616634
024 7 _a10.1007/978-1-60761-663-4
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
_dES-MaUEC
050 4 _aRM301.25
_b2010 EB
245 0 0 _aMicroarray Methods for Drug Discovery
_cedited by Sridar V. Chittur.
250 _a1st edition 2010
264 1 _aTotowa, NJ
_bHumana Press
_c2010
300 _a1 recurso en línea (XII, 284 páginas)
_b49 ilustraciones
336 _atexto
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
490 0 _aMethods in Molecular Biology
_x1940-6029
_v632
505 0 _aMulticenter Clinical Sample Collection for Microarray Analysis -- Isolation of Total RNA from Transgenic Mouse Melanoma Subsets Using Fluorescence-Activated Cell Sorting -- Microarray Analysis of Embryonic Stem Cells and Differentiated Embryoid Bodies -- Determination of Alternate Splicing Events Using the Affymetrix Exon 1.0 ST Arrays -- Profiling microRNA Expression with the Illumina BeadChip Platform -- TaqMan® Array Cards in Pharmaceutical Research -- DMET™ Microarray Technology for Pharmacogenomics-Based Personalized Medicine -- The Use of Microarray Technology for Cytogenetics -- PCR/LDR/Universal Array Platforms for the Diagnosis of Infectious Disease -- RIP-CHIP in Drug Development -- ChIPing Away at Global Transcriptional Regulation -- HELP (HpaII Tiny Fragment Enrichment by Ligation-Mediated PCR) Assay for DNA Methylation Profiling of Primary Normal and Malignant B Lymphocytes -- High-Throughput Screening of Metalloproteases Using Small Molecule Microarrays -- Metabolic Enzyme Microarray Coupled with Miniaturized Cell-Culture Array Technology for High-Throughput Toxicity Screening -- Use of Tissue Microarray to Facilitate Oncology Research -- Small Molecule Selectivity and Specificity Profiling Using Functional Protein Microarrays -- Production and Application of Glycan Microarrays.
520 _aWhile the utilization of microarrays for gene expression studies has been widely published, Microarray Methods for Drug Discovery describes the use of this technology for a multitude of other vital applications. Covering the field of drug discovery through its various aspects, including high throughput screening, target identification, drug metabolism and toxicity screening as well as clinical sample handling, this volume also addresses new emerging fields like miRNA profiling, ribonomic and glycomic profiling. All chapters, contributed by experts in the field, follow the highly successful Methods in Molecular Biology™ series format, which is comprised of brief introductions, lists of required materials and reagents, readily reproducible, step-by-step lab protocols, along with detailed tips on troubleshooting and avoiding known pitfalls, making this book an easy read for investigators at all levels of expertise. Authoritative and cutting-edge, Microarray Methods for Drug Discovery provides an ideal desk reference for scientists who wish to use microarray technology in order to better understand a variety of biological interactions in their respective fields.
988 _aSpringer_Protocols_2010
650 7 _2embne
_9137893
_aFarmacología
_xInvestigación
776 0 8 _iPrinted edition:
_z9781607616672
776 0 8 _iPrinted edition:
_z9781607616627
776 0 8 _iPrinted edition:
_z9781493957392
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-60761-663-4
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942 _2lcc
_cLE
998 _b12/2023
_dz
_ean
_zSI