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008			100917s2010 xxu| fo |||| 0|eng d
020			_a9781607618546
024	7		_a10.1007/978-1-60761-854-6 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQH324.2 _b2010 EB
245	1	0	_aComputational Biology of Transcription Factor Binding _cedited by Istvan Ladunga.
250			_a1st edition 2010
264		1	_aTotowa, NJ _bHumana Press _c2010
300			_a1 recurso en línea (XI, 454 páginas) _b102 ilustraciones, 9 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v674
505	0		_aAn Overview of the Computational Analyses and Discovery of Transcription Factor Binding Sites -- Components and Mechanisms of Regulation of Gene Expression -- Regulatory Regions in DNA: Promoters, Enhancers, Silencers, and Insulators -- Three-Dimensional Structures of DNA-Bound Transcriptional Regulators -- Identification of Promoter Regions and Regulatory Sites -- Motif Discovery Using Expectation Maximization and Gibbs' Sampling -- Probabilistic Approaches to Transcription Factor Binding Site Prediction -- The Motif Tool Assessment Platform (MTAP) for Sequence-Based Transcription Factor Binding Site Prediction Tools -- Computational Analysis of ChIP-seq Data -- Probabilistic Peak Calling and Controlling False Discovery Rate Estimations in Transcription Factor Binding Site Mapping from ChIP-seq -- Sequence Analysis of Chromatin Immunoprecipitation Data for Transcription Factors -- Inferring Protein-DNA Interaction Parameters from SELEX Experiments -- Kernel-Based Identification of Regulatory Modules -- Identification of Transcription Factor Binding Sites Derived from Transposable Element Sequences Using ChIP-seq -- Target Gene Identification via Nuclear Receptor Binding Site Prediction -- Computing Chromosome Conformation -- Large-Scale Identification and Analysis of C-Proteins -- Evolution of cis-Regulatory Sequences in Drosophila -- Regulating the Regulators: Modulators of Transcription Factor Activity -- Annotating the Regulatory Genome -- Computational Identification of Plant Transcription Factors and the Construction of the PlantTFDB Database -- Practical Computational Methods for Regulatory Genomics: A cisGRN-Lexicon and cisGRN-Browser for Gene Regulatory Networks -- Reconstructing Transcriptional Regulatory Networks Using Three-Way Mutual Information and Bayesian Networks -- Computational Methods for Analyzing Dynamic Regulatory Networks.
520			_aThrough great experimental difficulty, we've witnessed rapid, crucial developments at the intersection of computational biology, experimental technology, and statistics through which the vital process of transcriptional regulation can be further examined. In Computational Biology of Transcription Factor Binding, experts in the field examine the basic principles and provide detailed guidance for the computational analyses and biological interpretations of transcription factor binding, while disclosing critical practical information and caveats that are missing from many research publications. The volume serves not only computational biologists but experimentalists as well, who may want to better understand how to design and execute experiments and to communicate more effectively with computational biologists, computer scientists, and statisticians. Written for the highly successful Methods in Molecular Biology™ series, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results in the lab. Authoritative and easy to use, Computational Biology of Transcription Factor Binding guides scientists working in this area and demands not only new experiments but also the re-annotation of existing experimental data and computational predictions leading to important ongoing, major paradigm changes for us all.
988			_aSpringer_Protocols_2010
650		7	_2embne _9160489 _aBioinformática
776	0	8	_iPrinted edition: _z9781607618539
776	0	8	_iPrinted edition: _z9781607618553
776	0	8	_iPrinted edition: _z9781493961665
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-60761-854-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b12/2023 _dz _ean _zSI