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008			160812s2016 xxua o |||| 0|eng d
020			_a9781493963461
024	7		_a10.1007/978-1-4939-6346-1 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRA1199 _b2016 EB
245	0	0	_aHigh-Throughput Screening Assays in Toxicology _cedited by Hao Zhu, Menghang Xia
250			_a1st edition 2016
264		1	_aNew York, NY _bSpringer International Publishing _c2016
300			_a1 recurso en línea (XII, 175 páginas) _b50 ilustraciones, 32 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v1473
505	0		_aMonitoring Ligand-Activated Protein-Protein Interactions Using Bioluminescent Resonance Energy Transfer (BRET) Assay -- Mitochondrial Membrane Potential Assay -- Using β-Lactamase and NanoLuc Luciferase Reporter Gene Assays to Identify Inhibitors of the HIF-1 Signaling Pathway -- Quantitative High-Throughput Luciferase Screening in Identifying CAR Modulators -- Transactivation and Coactivator Recruitment Assays for Measuring Farnesoid X Receptor Activity -- Cell-Based Assay for Identifying the Modulators of Antioxidant Response Element Signaling Pathway -- Study Liver Cytochrome P450 3A4 Inhibition and Hepatotoxicity Using DMSO-Differentiated HuH-7 Cells -- Determination of Histone H2AX Phosphorylation in DT40 Cells -- High-Throughput and High Content Micronucleus Assay in CHO-K1 Cells -- Better, Faster, Cheaper: Getting the Most Out of High-Throughput Screening with Zebrafish -- Fast Functional Germline and Epigenetic Assays in the Nematode <Caenorhabditis elegans -- A Quantitative High-Throughput Screening Data Analysis Pipeline for Activity Profiling -- Correction of Microplate Data from High-Throughput Screening -- CurveP Method for Rendering High-Throughput Screening Dose-Response Data into Digital Fingerprints -- Accounting Artifacts in High-Throughput Toxicity Assays -- Accessing the High-Throughput Screening Data Landscape -- Curating and Preparing High Throughput Screening Data for Quantitative Structure Activity Relationship Modeling.
520			_aThis book focuses on recently developed High Throughput Screening (HTS) assay protocols, many involved in the ToxCast and/or Tox21 initiatives, and the relevant HTS data analysis techniques. Divided into three sections, in vitro assays, in vivo assays, and computational techniques to analyze HTS data are all examined. Written for the highly successful Methods in Molecular Biology series, most chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, High Throughput Screening Assays in Toxicology serves as a valuable reference resource for translating new HTS techniques into standardized chemical toxicity assessment tools in order to advance modern toxicology research to a new era where HTS techniques can partially replace the prevailing animal models.
988			_aSpringer_Protocols_2016
650		7	_2embne _9685999 _aEnsayos de toxicidad
776	0	8	_iPrinted edition: _z9781493963447
776	0	8	_iPrinted edition: _z9781493963454
776	0	8	_iPrinted edition: _z9781493981717
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-4939-6346-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b01/2024 _dz _eb _zSI