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008			100715s2009 xxu| fo |||| 0|eng d
020			_a9781597455626
024	7		_a10.1007/978-1-59745-562-6 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQP551 _b2009 EB
245	0	0	_aNeuroproteomics _bMethods and Protocols _cedited by Andrew K. Ottens, Kevin K.W. Wang
250			_a1st edition 2009
264		1	_aTotowa, NJ _bHumana Press _c2009
300			_a1 recurso en línea (XI, 321 páginas) _b51 ilustraciones
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v566
505	0		_aDisease Models in Neuroproteomics -- The Methodology of Neuroproteomics -- Modeling Cerebral Ischemia in Neuroproteomics -- Clinical and Model Research of Neurotrauma -- Neuroproteomic Methods in Spinal Cord Injury -- Modeling Substance Abuse for Applications in Proteomics -- Protein Aggregate Characterization in Models of Neurodegenerative Disease -- Sub-Proteome Separations and Neuroproteomic Analysis -- Sub-Proteome Processing: Isolation of Neuromelanin Granules from the Human Bra -- Proteomic Analysis of Protein Phosphorylation and Ubiquitination in Alzheimer's Disease -- Proteomics Identification of Carbonylated and HNE-Bound Brain Proteins in Alzheimer's Disease -- Mass Spectrometric Identification of In Vivo Nitrotyrosine Sites in the Human Pituitary Tumor Proteome -- Improved Enrichment and Proteomic Analysis of Brain Proteins with Signaling Function by Heparin Chromatography -- Calmodulin-Binding Proteome in the Bra -- Neuroproteomic Methodology and Bioinformatics -- Separation of the Neuroproteome by Ion Exchange Chromatography -- iTRAQ-Based Shotgun Neuroproteomics -- Methods in Drug Abuse Neuroproteomics: Methamphetamine Psychoproteome -- Shotgun Protein Identification and Quantification by Mass Spectrometry in Neuroproteomics -- Biofluid Analysis and Clinical Translation -- Identification of Glycoproteins in Human Cerebrospinal Fluid -- Mass Spectrometric Analysis of Body Fluids for Biomarker Discovery -- Traumatic Brain Injury Biomarkers: From Pipeline to Diagnostic Assay Development -- Translation of Neurological Biomarkers to Clinically Relevant Platforms.
520			_aWith the development of polypeptide ionization processes for mass spectrometry and the rapid processing of large-scale datasets with bioinformatics, researchers now have the tools necessary to propel neuroproteomics research to new levels. In Neuroproteomics: Methods and Protocols, experts in the neurological and analytical sciences present experimental details for applying proteomics to the study of the central nervous system (CNS) and its dysfunction through trauma and disease. Divided into four convenient sections, this collection covers CNS animal models used for neuroproteomics research, methods for separating and analyzing discrete subcomponents of the neuroproteome, large-scale approaches for CNS proteome characterization and quantification, as well as methods that evaluate biofluids and translate neuroproteomic results into clinical platforms. As a volume in the highly successful Methods in Molecular Biology™ series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Neuroproteomics: Methods and Protocols includes the clear "how-to" information needed to critically assess what can be accomplished in the field and how to best perform and evaluate neuroproteomic experiments in one's own research.
988			_aSpringer_Protocols_2009
650		7	_2embne _9430647 _aProteómica
776	0	8	_iPrinted edition: _z9781607610793
776	0	8	_iPrinted edition: _z9781934115848
776	0	8	_iPrinted edition: _z9781617797545
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-59745-562-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b12/2023 _dz _ean _zSI