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020 _a9781607617501
024 7 _a10.1007/978-1-60761-750-1
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
_dES-MaUEC
050 4 _aRC337
_b2010 EB
245 0 0 _aRodent Models of Stroke
_cedited by Ulrich Dirnagl
250 _a1st edition 2010
264 1 _aTotowa, NJ
_bHumana Press
_c2010
300 _a1 recurso en línea (XII, 285 páginas)
_b49 ilustraciones
336 _atexto
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
490 0 _aNeuromethods
_x1940-6045
_v47
505 0 _aFrom Bedside to Bench: How Clinical Reality Should Instruct Stroke Modeling -- How to Avoid Bumping into the Translational Roadblock -- Modeling Focal Cerebral Ischemia in Rodents: Introduction and Overview -- Focal Cerebral Ischemia in the Mouse and Rat Using the Intraluminal Suture-Filament Model -- Focal Ischemia Models: Middle Cerebral Artery Occlusion Induced by Electrocoagulation, Occluding Devices, and Endothelin-1 -- Rodent Models of Thromboembolic Stroke -- Photochemical and Endothelin Models of Focal Brain Ischemia -- Housing in an Enriched Environment: A Tool to Study Functional Recovery After Experimental Stroke -- Modeling Risk Factors and Confounding Effects in Stroke -- Effect of Anesthesia in Stroke Models -- Noninvasive Brain Imaging in Small Animal Stroke Models: MRI and PET -- Non-invasive Optical Imaging in Small Animal Models of Stroke -- Behavioral Testing in Mouse Models of Stroke -- Behavioral Testing in Rodent Models of Stroke -- Histology and Infarct Volume Determination -- Ethics of Modeling of Cerebral Ischemia in Small Animals -- Quality Control and Standard Operating Procedures -- Statistics in Experimental Stroke Research: From Sample Size Calculation to Data Description and Significance Testing -- Complexities, Confounders, and Challenges in Experimental Stroke Research: A Checklist for Researchers and Reviewers.
520 _aIn view of the numerous failures of clinical trials aimed at improving stroke therapy, the role and potential benefit of experimentally modeling focal cerebral ischemia in rodents has been debated. When methods of systematic review and metaanalyis are applied, however, it turns out that experimental models actually faithfully predicted the negative outcomes of clinical trials. In addition, thrombolysis and neuroprotection by hypothermia, first described in animal models, are key examples of treatment modalities that have made it successfully into clinical practice. In Rodent Models of Stroke, an international consortium of authors aims at critically addressing the issues on a very practical level, from choosing the model and outcome measures, designing the experiment, conducting and analyzing it, to reporting it in a scientific publication. The structure and content of the book reflect both the authors' longstanding expertise in experimental and clinical stroke research and their roles in training the scientific community in the tools of the trade. As a volume in the successful Neuromethods series, the chapters provide authoritative reviews of the most commonly used, well-honed approaches in the field today. Stimulating and easy-to-use, Rodent Models of Stroke will help its readers understand the limitations and the opportunities of modeling stroke in rodents and enable them to conduct experiments which will not only improve our understanding of the pathophysiology of this devastating disorder but also serve as the basis for developing new highly effective treatments.
988 _aSpringer_Protocols_2010
650 7 _2embne
_9673393
_aRoedores
_xFisiología
776 0 8 _iPrinted edition:
_z9781607617518
776 0 8 _iPrinted edition:
_z9781607617495
776 0 8 _iPrinted edition:
_z9781493958078
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-60761-750-1
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942 _2lcc
_cLE
998 _b12/2023
_dz
_ean
_zSI