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001			392926
003			ES-MaUEC
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007			cr nn 008mamaa
008			100825s2010 xxu| s |||| 0|eng d
020			_a9781607617594
024	7		_a10.1007/978-1-60761-759-4 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aCancer Susceptibility _bMethods and Protocols _cedited by Michelle Webb.
250			_a1st edition 2010
264		1	_aTotowa, NJ _bHumana Press _c2010
300			_a1 recurso en línea (XI, 295 páginas) _b
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v653
505	0		_aIdentifying Cancer Susceptibility Genes -- The Identification of Colon Cancer Susceptibility Genes by Using Genome-Wide Scans -- Prioritizing Candidate Genetic Modifiers of BRCA1 and BRCA2 Using a Combinatorial Analysis of Global Expression and Polymorphism Association Studies of Breast Cancer -- Microarray-Based Comparative Genomic Hybridization (Array-CGH) as a Useful Tool for Identifying Genes Involved in Glioblastoma (GB) -- Multiplex Amplifiable Probe Hybridization (MAPH) Methodology as an Alternative to Comparative Genomic Hybridization (CGH) -- Utilizing Saccharomyces Cerevisiae to Identify Aneuploidy and Cancer Susceptibility Genes -- Computational Identification of Cancer Susceptibility Loci -- Digital Candidate Gene Approach (DigiCGA) for Identification of Cancer Genes -- Screening Cancer Susceptibility Genes -- The Use of Denaturing High Performance Liquid Chromatography (DHPLC) for Mutation Scanning of Hereditary Cancer Genes -- Enhanced Mismatch Mutation Analysis: Simultaneous Detection of Point Mutations and Large Scale Rearrangements by Capillary Electrophoresis, Application to BRCA1 and BRCA2 -- Economical Protocol for Combined Single-Strand Conformation Polymorphism and Heteroduplex Analysis on a Standard Capillary Electrophoresis Apparatus -- Mutational Screening of hMLH1 and hMSH2 that Confer Inherited Colorectal Cancer Susceptibility Using Denature Gradient Gel Electrophoresis (DGGE) -- s-RT-MELT: A Novel Technology for Mutation Screening -- Zoom-In Array Comparative Genomic Hybridization (aCGH) to Detect Germline Rearrangements in Cancer Susceptibility Genes -- Development of a Scoring System to Screen for BRCA1/2 Mutations -- Use of Splicing Reporter Minigene Assay to Evaluate the Effect on Splicing of Unclassified Genetic Variants -- Functional Analysis of Human BRCA2 Variants Using a Mouse Embryonic Stem Cell-Based Assay -- Developing Functional Assays for BRCA1 Unclassified Variants.
520			_aOver the past two decades, spectacular advances have been made in our understanding of the molecular genetics of cancer, leading to the pursuit of identifying genes that, when mutated, result in an increased susceptibility to the disease. In Cancer Susceptibility: Methods and Protocols, experts in the field bring together the most recent technological developments for identifying and screening cancer susceptibility genes. Divided into two clear sections, the book begins with gene identification, which updates and informs scientists working at identifying novel cancer susceptibility genes, while the second part deals with mutation screening technologies that aid scientists and clinicians working to translate this knowledge into the clinic. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cancer Susceptibility: Methods and Protocols is a timely collection that seeks to provide researchers with the tools to predict and combat this terrible disease.
700	1		_aWebb, Michelle _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781607617587
776	0	8	_iPrinted edition: _z9781607617600
776	0	8	_iPrinted edition: _z9781493957606
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-60761-759-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
988			_aSpringer_Protocols_2010
999			_c392926 _d392926