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008			111207s2012 xxu| fo |||| 0|eng d
020			_a9781617794216
024	7		_a10.1007/978-1-61779-421-6 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRA1224.3 _b2012 EB
245	0	0	_aGenetic Toxicology _bPrinciples and Methods _cedited by James M. Parry, Elizabeth M. Parry
250			_a1st edition 2012
264		1	_aTotowa, NJ _bHumana Press _c2012
300			_a1 recurso en línea (XVI, 433 páginas) _b114 ilustraciones, 46 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v817
505	0		_aThe Application of Structure Activity Relationships to the Prediction of the Mutagenic Activity of Chemicals -- Bacterial Mutagenicity Assays: Test Methods -- The Mouse Lymphoma Assay -- Mammalian Cell HPRT Gene Mutation Assay: Test Methods -- The In Vitro Mammalian Chromosome Aberration Test -- The Interpretation and Analysis of Cytogenetic Data -- The In Vitro Micronucleus Assay -- The In Vitro and In Vivo Comet Assays -- Assessment of DNA Interstrand Crosslinks (ICLs) Using the Modified Alkaline Comet Assay -- 32P-Postlabelling for the Sensitive Detection of DNA Adducts -- Methods for the Detection of DNA Adducts -- The GADD45a-GFP GreenScreen HC Assay -- Real Time Reverse-Transcription Polymerase Chain Reaction (RT-PCR): Technical Considerations for Gene Expression Analysis -- Cytogenetic In Vivo Assays in Somatic Cells -- Cytogenetic Methods in Human Biomonitoring: Principles and Uses -- The Measurement of Induced Genetic Change in Mammalian Germ Cells -- Transgenic Animal Mutation Models: A Review of the Models and How They Function -- Analysis of Genotoxicity Data in a Regulatory Context.
520			_aThe evaluation of potential mutagenic activity is a critical step in the assessment of the safety of both new and pre-existing chemical types. In Genetic Toxicology: Principles and Methods, expert contributors help to satisfy the demand for education in this tremendously important area of study.  The volume covers three basic areas: the scientific basis of the discipline, the methodologies of the main test assays, and the application of the methods, all aimed primarily at scientists in the safety departments of the industries working with both natural and synthetic chemicals.  Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.   Intuitive and cutting-edge, Genetic Toxicology: Principles and Methods provides crucial support to both laboratory workers in providing quality information on the appropriate application of techniques and to study directors in their assay selection and protocol design in this vital field.
988			_aSpringer_Protocols_2012
650		7	_2embne _9140562 _aGenética humana
776	0	8	_iPrinted edition: _z9781617794209
776	0	8	_iPrinted edition: _z9781617794223
776	0	8	_iPrinted edition: _z9781493957361
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-61779-421-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b11/2023 _dz _ean _zSI