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008			100715s2010 xxu| o |||| 0|eng d
020			_a9781607614012
024	7		_a10.1007/978-1-60761-401-2 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050			_aRC582.17 _b2010 EB
245	0	0	_aImmunotoxicity Testing : _bMethods and Protocols _cedited by Rodney R. Dietert
250			_a1st edition 2010
264		1	_aTotowa, NJ _bHumana Press _c2010
300			_a1 recurso en línea (X, 430 páginas) _b43 ilustraciones
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v598
505	0		_aImmunotoxicology Testing: Past and Future -- Overview and Health-Risk Considerations -- Developmental Immunotoxicity (DIT): The Why, When, and How of DIT Testing -- An In Vivo Tiered Approach to Test Immunosensitization by Low Molecular Weight Compounds -- Risk of Autoimmune Disease: Challenges for Immunotoxicity Testing -- Markers of Inflammation -- Evaluating Macrophages in Immunotoxicity Testing -- Immunotoxicity and Host Resistance Models -- Host Resistance Assays Including Bacterial Challenge Models -- Viral Host Resistance Studies -- Parasite Challenge as Host Resistance Models for Immunotoxicity Testing -- Tumor Challenges in Immunotoxicity Testing -- Testing Protocols in Rodents and Other Laboratory Animals -- The T-Dependent Antibody Response to Keyhole Limpet Hemocyanin in Rodents -- The Sheep Erythrocyte T-Dependent Antibody Response (TDAR) -- The Delayed Type Hypersensitivity Assay Using Protein and Xenogeneic Cell Antigens -- The Cytotoxic T Lymphocyte Assay for Evaluating Cell-Mediated Immune Function -- NK Cell Assays in Immunotoxicity Testing -- The Local Lymph Node Assay and Skin Sensitization Testing -- Use of Contact Hypersensitivity in Immunotoxicity Testing -- Evaluation of Apoptosis in Immunotoxicity Testing -- Dendritic Cells in Immunotoxicity Testing -- Evaluating Cytokines in Immunotoxicity Testing -- Flow Cytometry in Preclinical Drug Development -- Enhanced Histopathology Evaluation of Lymphoid Organs -- Immunotoxicity Testing in Nonhuman Primates -- Evaluation in Humans -- Fundamentals of Clinical Immunotoxicology -- Wildlife Testing -- In Vivo Functional Tests for Assessing Immunotoxicity in Birds -- In Vitro Alternatives -- In Vitro Testing for Direct Immunotoxicity: State of the Art.
520			_aRecent critical advances in the field of immunotoxicology have led to incredible contributions to basic science, including crucial improvements in human risk assessment. In Immunotoxicity Testing: Methods and Protocols, expert researchers explore these changes, providing the reader with current, lab-ready procedures, along with the corresponding background information that is necessary to identify effective testing approaches for chemicals and drugs. Among the first volumes to meld consideration of immunotoxicity testing strategies with a comprehensive presentation of detailed laboratory protocols, chapters include a description of the evolution of immunotoxicity testing, a look at the importance of immunotoxicity testing for health risk reduction, and ideas concerning the future of the field. Composed in the highly successful Methods in Molecular Biology(tm) series format, most chapters contain a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips from the experts on troubleshooting and avoiding known pitfalls. Comprehensive and innovative, Immunotoxicity Testing: Methods and Protocols is a critical, one-stop reference resource for the most important and commonly used laboratory protocols in immunotoxicology.
988			_aSpringer_Protocols_2010
650		7	_2embne _9138330 _aInmunología _vManuales de laboratorio
650		7	_2embne _9140328 _aToxicología _vManuales de laboratorio
776	0	8	_iPrinted edition: _z9781607614029
776	0	8	_iPrinted edition: _z9781607614005
776	0	8	_iPrinted edition: _z9781493957316
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-60761-401-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b11/2023 _dz _eu _zSI