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008			100301s2003 xxu| o |||| 0|eng d
020			_a9781592593484
024	7		_a10.1385/1592593488 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC455.4 .G4 _b2003 EB
245	0	0	_aPsychiatric Genetics : _bMethods and Reviews _cedited by Marion Leboyer, Frank Bellivier
250			_a1st edition 2003
264		1	_aTotowa, NJ _bHumana Press _c2003
300			_a1 recurso en línea (IX, 268 páginas) _b7 ilustraciones
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Medicine _x1940-6037 _v77
505	0		_aPsychiatric Genetics -- Methods in Psychiatric Genetics: Advantages and Limits -- Analytical Methods Applied to Psychiatric Genetics -- Genetic Markers in Psychiatric Genetics -- Clinical Assessment in Psychiatric Genetics -- Genetic Association Studies -- New Phenotypic Approaches -- Searching for Alternative Phenotypes in Psychiatric Genetics -- Intermediate Cognitive Phenotypes Associated with Schizophrenia -- Biochemical Endophenotypes in Personality Disorders -- Electrophysiological Phenotypes -- Brain Imaging as an Approach to Phenotype Characterization for Genetic Studies of Schizophrenia -- Conclusion -- Psychiatric Genetics.
520			_aEnthusiasm about the role that genetics plays in our understanding of behavioral phenotypes has led to the development of many new epidemiological and statistical strategies, as well as to refinements in phenotype analysis. In Psychiatric Genetics: Methods and Reviews, hands-on experts comprehensively review the tools and methods currently available to uncover the genetic basis of psychiatric disorders, and then demonstrate through archetypical examples how these strategies can be used. Casting their net widely, the authors critically examine the key methodological issues involved in phenotypic analysis-including study design, molecular techniques, clinical interviews, and population sampling methods-and discuss new and alternate strategies that identify candidate symptoms and endophenotypes with better genetic validity. These strategies suggest cognitive intermediate phenotypes in schizophrenia, show how personality disorders may generate biologically mediated traits in the full-blown disorders, and yield data about P50 and P300 as endophenotypes in schizophrenia and alcoholism. One of the most promising approaches for the identification of valid phenotypes-the union of neuropsychological experimental designs and in vivo physiological brain mapping-is also discussed. Practical and timely, Psychiatric Genetics: Methods and Reviews lays the cornerstone for the new diagnostics in psychiatric genetics-the unraveling of the genetic basis of psychiatric disorders and the development of new therapies through the precise identification of the phenotypes involved.
988			_aSpringer_Protocols_2003
650		7	_9291096 _aEnfermedades mentales _xAspectos genéticos _vManuales de laboratorio
776	0	8	_iPrinted edition: _z9781489938459
776	0	8	_iPrinted edition: _z9781588290373
776	0	8	_iPrinted edition: _z9781489938442
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1385/1592593488 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b11/2023 _dz _eu _zSI