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008			110603s2011 xxu| fo |||| 0|eng d
020			_a9781617791574
024	7		_a10.1007/978-1-61779-157-4 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC514 _b2011 EB
245	0	0	_aAnimal Models of Schizophrenia and Related Disorders _cedited by Patricio O'Donnell
250			_a1st edition 2011
264		1	_aTotowa, NJ _bHumana Press _c2011
300			_a1 recurso en línea (XII, 290 páginas) _b51 ilustraciones
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aNeuromethods _x1940-6045 _v59
505	0		_aA Method to the Madness:  Producing the Neonatal Ventral Hippocampal Lesion Rat Model of Schizophrenia -- Gestational MAM (Methylazoxymethanol Acetate) Administration: A Promising Animal Model for Psychosis Onset -- Prenatal Infection and Immune Models of Schizophrenia -- The Hypoxic Rat Model for Obstetric Complications in Schizophrenia -- The Developmental Vitamin D (DVD) Model of Schizophrenia -- Studying Schizophrenia in a Dish: Use of Primary Neuronal Cultures to Study the Long Term Effects of NMDA Receptor Antagonists on Parvalbumin-Positive Fast-Spiking Interneurons -- Glutathione Deficit and Redox Dysregulation in Animal Models of Schizophrenia -- Psychiatric Genetics and the Generation of Mutant Animal Models -- DISC1 Mouse Models -- Genetically-Engineered Mice for Schizophrenia Research -- Epigenetic Animal Models of GABAergic Deficit in Mental Disorders -- Modeling Schizophrenia in Neuregulin 1 and ErbB4 Mutant Mice.
520			_aAnimal models of schizophrenia and other major psychiatric disorders have been sought for decades, and, as a result, we are now facing new vistas on pathophysiology that could lead to novel therapeutic approaches and even hint at possible preventive strategies. Animal Models of Schizophrenia and Related Disorders presents an overview of the information that can be obtained with several different models and a detailed account of how to generate such models in order to ensure that the manipulations used to model schizophrenia-relevant phenomena are used consistently across laboratories.  This detailed volume features pharmacological models such as non-competing NMDA antagonists, emphasizing their use in vitro, neurodevelopmental models such as the neonatal ventral hippocampal lesion and the antimitotic MAM, models that reproduce environmental factors such as neonatal hypoxia, vitamin D deficits, and prenatal immune activation, as well as several different genetic model approaches.  As a volume in the Neuromethods series, this volume contains the kind of detailed description and implementation advice that is crucial for getting optimal results.   Practical and cutting-edge, Animal Models of Schizophrenia and Related Disorders highlights the successes in the use of animal models to gain insight on pathophysiological mechanisms of relevance to major psychiatric disorders in the hope of inspiring investigators to expand the research and test targets that could restore or ameliorate function.
988			_aSpringer_Protocols_2011
650		7	_2embne _9140524 _aEsquizofrenia
776	0	8	_iPrinted edition: _z9781617791567
776	0	8	_iPrinted edition: _z9781617791581
776	0	8	_iPrinted edition: _z9781493957880
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-61779-157-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b10/2023 _dz _ean _zSI