000			04535nam a22004215i 4500
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003			ES-MaUEC
005			20231118192833.0
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007			cr nn 008mamaa
008			100701s2009 xxu| fo |||| 0|eng d
020			_a9781603275477
024	7		_a10.1007/978-1-60327-547-7 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQP623.5 .S63 _b2009 EB
245	0	0	_asiRNA and miRNA Gene Silencing : _bFrom Bench to Bedside _cedited by Mouldy Sioud
250			_a1st edition 2009
264		1	_aTotowa, NJ _bHumana Press _c2009
300			_a1 recurso en línea (XIV, 472 páginas)
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v487
505	0		_aMethods for Selecting Effective siRNA Sequences by using Statistical and Clustering Techniques -- Deciphering the Code of Innate Immunity Recognition of siRNAs -- Targeted Delivery of Antisense Oligonucleotides and siRNAs into Mammalian Cells -- Local and Systemic Delivery of siRNAs for Oligonucleotides Therapy -- Imaging of siRNA Delivery and Silencing -- Recent Advances in Magnetofection and Its Potential to Deliver siRNAs In Vitro -- In Vitro and In Vivo Gene Silencing by TransKingdom RNAi (tkRNAi) -- Bacterial Delivery of siRNAs: A New Approach to Solid Tumor Therapy -- The Therapeutic Potential of LNA-modified siRNAs: Reduction of Off-target Effects by Chemical Modification of the siRNA Sequence -- pSM155 and pSM30 Vectors for miRNA and shRNA Expression -- Targeting Oncogenes with siRNAs -- Targeting Stromal-cancer Cell Interactions with siRNAs -- Therapeutic Potential of siRNA-mediated Targeting of Urokinase Plasminogen Activator, Its Receptor, and Matrix Metalloproteinases -- Silencing of HIF-1#x03B1; by RNA Interference in Human Glioma Cells In Vitro and In Vivo -- RNA Interference-Mediated Validation of Genes Involved in Telomere Maintenance and Evasion of Apoptosis as Cancer Therapeutic Targets -- Treating Respiratory Viral Diseases with Chemically Modified, Second Generation Intranasal siRNAs -- Progress in the Therapeutic Applications of siRNAs Against HIV-1 -- Protein Components of the microRNA Pathway and Human Diseases -- Intron-Mediated RNA Interference and microRNA Biogenesis -- Emergence of a Complex Relationship between HIV-1 and the microRNA Pathway -- Synthetic microRNA Targeting Glioma-associated Antigen-1 Protein -- Therapeutic Targeting of Gene Expression by siRNAs Directed Against BCR-ABL Transcripts in a Patient with Imatinib-Resistant Chronic Myeloid Leukemia.
520			_aRNA interference has become a key method in the suppression of gene expression and the development of therapeutic agents, yet there is still the problem of delivery, stability, and the danger of off-target effects such as the silencing of unwanted genes and activation of innate immunity. In siRNA and miRNA Gene Silencing: From Bench to Bedside, expert researchers explore the most recent advances in siRNA design, expression, delivery, in vivo imaging, and methods to minimize siRNA's unwanted effects and promote successful use in patients. As part of the highly successful Methods in Molecular Biology™ series, the chapters focus on their respective subjects with easy-to-use, up-to-date information, including several step-by-step laboratory protocols on topics such as new delivery formulations and strategies with promising applications in vitro and in vivo, validated therapeutic target genes, and components of miRNA function, biogenesis, and interference with virus infection. Comprehensive and cutting-edge, siRNA and miRNA Gene Silencing: From Bench to Bedside offers an excellent collection of chapters to aid all those with an interest in RNAi, gene regulation, and new therapies.
988			_aSpringer_Protocols_2009
650		7	_2embne _9144940 _aARN
650		7	_2embne _9140562 _aGenética humana
650		7	_2embne _9162770 _aExpresión génica
776	0	8	_iPrinted edition: _z9781607610533
776	0	8	_iPrinted edition: _z9781617379086
776	0	8	_iPrinted edition: _z9781603275460
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-60327-547-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b11/2023 _dz _ean _zSI