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008			100715s2010 xxu| o |||| 0|eng d
020			_a9781607615293
024	7		_a10.1007/978-1-60761-529-3 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRS199.5 _b2010 EB
245	0	0	_aDrug Delivery to the Central Nervous System _cedited by Kewal K. Jain
250			_a1st edition 2010
264		1	_aTotowa, NJ _bHumana Press _c2010
300			_a1 recurso en línea (XII, 324 páginas) _b98 ilustraciones, 4 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aNeuromethods _x1940-6045 _v45
505	0		_aAn Overview of Drug Delivery to the CNS -- Receptor-Mediated Transport of Drugs Across the BBB -- Disruption of Blood-Brain Barrier by Focused Ultrasound for Targeted Drug Delivery to the Brain -- Prediction of Blood-Brain Barrier Penetration by Drugs -- Intraparenchymal Delivery and Its Discontents -- Intrathecal Drug Delivery by Implanted Pumps -- Intracarotid Drug Delivery: Revisiting the Past or Looking into the Future -- Vesicular Systems for Intranasal Drug Delivery -- Convection-Enhanced Drug Delivery and Monitoring in a Rat Model -- Intrathecal Delivery of Stem Cells to the Spinal Cord -- CNS Delivery of Peptides Across the BBB Using the Dual-Artery In Situ Brain Perfusion Model -- An Engineered Peptide Compound Platform Technology Incorporating Angiopep for Crossing the BBB -- Adeno-Associated Virus Mediated Gene Therapy in Ischemic Stroke -- Use of Mesenchymal Stem Cells for Gene Delivery to Intracranial Glioma -- Convection-Enhanced Drug Delivery to the Brain.
520			_aPlaying an important role in the treatment of neurological disorders, the delivery of drugs to central nervous system (CNS), both administered directly and administered systematically for targeted action, encounters a major challenge in the form of the blood-brain barrier (BBB), which limits the access of drugs to the brain substance. In Drug Delivery to the Central Nervous System, experts in the field present essential methods used to deliver therapeutics across the BBB, both in experimental animals and in humans. In addition to those methods, several overviews of innovative methods and their applications are presented in order to give a glimpse of the future of this research. As a volume in the successful Neuromethods series, this book presents its protocols with the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and cutting-edge, Drug Delivery to the Central Nervous System serves as an ideal guide to scientists continuing to pursue knowledge of the delicate interactions between pharmaceuticals and the brain.
988			_aSpringer_Protocols_2010
650		7	_2embne _9188115 _aSistema nervioso central _xEnfermedades
776	0	8	_iPrinted edition: _z9781607615316
776	0	8	_iPrinted edition: _z9781607615286
776	0	8	_iPrinted edition: _z9781493961597
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-60761-529-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b09/2023 _dz _eIG _zSI