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007			cr nn 008mamaa
008			100301s1996 xxu| fo |||| 0|eng d
020			_a9781592595853
024	7		_a10.1385/0896033058 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050			_aRM666.A564 _b1996 EB
245	0	0	_aAntisense Therapeutics _cedited by Sudhir Agrawal.
250			_a1st edition 1996
264		1	_aTotowa, NJ _bHumana Press _c1996
300			_a1 recurso en línea (XIII, 277 páginas)
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Medicine _x1940-6037 _v1
505	0		_aHistory of Antisense Oligonucleotides -- Pharmacology of Antisense Therapeutic Agents -- Antisense Efficacy -- Antisense Blockade of Expression -- Antisense Tumor Therapy -- Antisense Inhibition of Protein Synthesis and Function -- c-Myb in Smooth Muscle Cells -- Antisense Therapy of Hepatitis B Virus Infection -- Antisense-Mediated Inhibition of Protein Synthesis -- Antisense rel A in Cancer -- Continuous Infusion of Antisense Phosphorothioate Therapeutics -- Protein Kinase-A Directed Antisense Therapy of Tumor Growth In Vivo -- Antisense Therapeutics in the Central Nervous System -- Comparative Pharmacokinetics of Antisense Oligonucleotides.
520			_aLeading researchers offer an authoritative survey and analysis of the latest findings on the rapid development of antisense oligonucleotides therapeutic and their application in various in vivo model systems. The book's high-profile contributors provide timely accounts of their state-of-the-art strategies, discussing such topics as the synthesis and purification of oligonucleotides, their selection for a particular gene target, different methods of administration, and the use of various cell lines and cell culture systems. They also examine questions of cellular uptake, in vitro biological activity, in vivo biological activity, the pharmacology and pharmacokinetics of oligonucleotides, and the application of oligonucleotides to the central nervous system.
988			_aSpringer_Protocols_1996
650		7	_2embne _9140525 _aÁcidos nucleicos
650		7	_2embne _9137893 _aFarmacología _vManuales de laboratorio
650		7	_2embne _9144940 _aARN
776	0	8	_iPrinted edition: _z9781489940841
776	0	8	_iPrinted edition: _z9780896033054
776	0	8	_iPrinted edition: _z9781489940834
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1385/0896033058 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b09/2023 _dz _ean _zSI