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008			150406s2015 xxua o |||| 0|eng d
020			_a9781493926176
024	7		_a10.1007/978-1-4939-2617-6 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aR857 .B54 _b2015 EB
245	0	0	_aLabel-Free Biosensor Methods in Drug Discovery _cedited by Ye Fang
250			_a1st edition 2015
264		1	_aNew York, NY _bSpringer International Publishing _c2015
300			_a1 recurso en línea (XI, 390 páginas) _b114 ilustraciones, 93 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Pharmacology and Toxicology _x1940-6053
505	0		_aLabel-Free Technologies: Which Technique to Use and What to Watch Out For! -- Label-Free Cell Phenotypic Profiling and Screening: Techniques, Experimental Design, and Data Assessment -- Surface Plasmon Resonance for Therapeutic Antibody Characterization -- Label-Free Cell-Based Biosensor Methods in Drug Toxicology Analysis -- Kinetics Characterization of Ligand-Receptor Interactions Using Oblique-Incidence Reflectivity Difference Method -- Label-Free Inhibition in Solution Assays for Fragment Screening -- Silicon Photonic Micro-Ring Resonators for Drug Screening and Kinetic Analysis -- Optical Waveguide Light-Mode Spectroscopy for Ion Channel Profiling -- Label-Free Profiling of Endogenous Receptor Responses in Primary Isolated Cardiac Cells -- Surface Plasmon Resonance to Study Cell Signaling and GPCR Functional Selectivity in Live Cells -- Triple-Addition Label-Free Assays for High Throughput Screening of Muscarinic M1 Receptor Agonists, Antagonists, and Allosteric Modulators -- Multiplexing Label-Free and Florescence-Based Methods for Pharmacological Characterization of GPCR Ligands -- Label-Free Cell Phenotypic Identification of Active Compounds in Traditional Chinese Medicines -- Use of the Quartz Crystal Microbalance with Dissipation Monitoring for Pharmacological Evaluation of Cell Signaling Pathways Mediated by Epidermal Growth Factor Receptors -- Profiling Sodium-Dependent Phosphate Transporter NaPi-IIb with Resonant Waveguide Grating Biosensor -- Label-Free Impedance Measurements for Profiling Drug-Induced Cardiotoxicity -- Digital Holographic Imaging for Label-Free Phenotypic Profiling, Cytotoxicity, and Chloride Channels Target Screening -- Label-Free Profiling of Cell Adhesion: Determination of the Dissociation Constant for Native Cell Membrane Adhesion Receptor-Ligand Interaction -- Label-Free Impedance-Based Monitoring of Cell Migration and Invasion -- Infrared Surface Plasmon Spectroscopy Decodes Early Processes in Epithelial Host Cells Upon Enteropathogenic Escherichia coli Infection -- Surface Plasmon Resonance for Clinical Diagnosis of Type I Allergy.
520			_aThis volume explores label-free biosensors, advantageous in part because this technology bypasses the need of labels, reporters, and cell engineering, all of which are common to labeled techniques but may introduce artifacts in assay results. Addressing several fundamental and practical aspects as to how to implement label-free methods in the drug discovery process, this book covers a wide range of topics, including binding kinetics determination, fragment screening, antibody epitope mapping, protein-protein interaction profiling and screening, receptor pathway deconvolution, drug pharmacology profiling and screening, target identification, drug toxicity assessment, and physical phenotype profiling and diagnostics based on various cellular processes such as cell adhesion, migration, invasion, infection, and inflammation. As part of the Methods in Pharmacology and Toxicology series, chapters aim to provide key detail and implementation advice to aid with progress in the lab. Practical and thorough, Label-Free Biosensor Methods in Drug Discovery provides a new avenue for rapid access to a focused collection of highly regarded contributions in the field.
988			_aSpringer_Protocols_2015
650		7	_2embne _9158891 _aBiosensores _vManuales de laboratorio
776	0	8	_iPrinted edition: _z9781493926183
776	0	8	_iPrinted edition: _z9781493926169
776	0	8	_iPrinted edition: _z9781493949618
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-4939-2617-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b10/2023 _dz _eb _zSI