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007			cr nn 008mamaa
008			101218s2011 xxu o |||| 0|eng d
020			_a9781607618980
024	7		_a10.1007/978-1-60761-898-0 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC521 _b2011 EB
245	0	0	_aAnimal Models of Dementia _cedited by Peter Paul De Deyn, Debby Van Dam
250			_a1st edition 2011
264		1	_aTotowa, NJ _bHumana Press _c2011
300			_a1 recurso en línea (XVI, 732 páginas)
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aNeuromethods _x1940-6045 _v48
505	0		_aGeneral Introduction to Animal Models of Human Conditions -- Animal Models of Dementia: Ethical Considerations -- The Role of Rodent Models in the Drug Discovery Pipeline for Dementia -- Species, Strain, and Gender Issues in the Development and Validation of Animal Models of Dementia -- Transgenic and Gene Targeted Models of Dementia -- Transgenic Animals and Intellectual Property Concerns -- Pathological Validation of Animal Models of Dementia -- Behavioral Validation in Animal Models of Dementia -- Pharmacological Validation in Animal Models of Dementia -- Validation of Animal Models of Dementia: Neurochemical Aspects -- Validation of Dementia Models Employing Neuroimaging Techniques -- Drosophila melanogaster as a Model Organism for Dementia -- Caenorhabditis elegans as a Model Organism for Dementia -- Zebrafish (Danio rerio) as a Model Organism for Dementia -- Spontaneous Vertebrate Models of Alzheimer Dementia: Selectively Bred Strains (SAM Strains) -- Lesion-Induced Vertebrate Models of Alzheimer Dementia -- Aβ Infusion and Related Models of Alzheimer Dementia -- APP-Based Transgenic Models: The PDAPP Model -- APP-Based Transgenic Models: The Tg2576 Model -- APP-Based Transgenic Models: The APP23 Model -- Presenilin-Based Transgenic Models of Alzheimer's Dementia -- APOE-Based Models of "Pre-Dementia" -- TAU Models -- The 3xTg-AD Mouse Model: Reproducing and Modulating Plaque and Tangle Pathology -- Cognitive Dysfunction in Genetic Mouse Models of Parkinsonism -- Mouse Models of Metachromatic Leukodystrophy and Adrenoleukodystrophy -- Animal Models of Amyotrophic Lateral Sclerosis -- Animal Models of Frontotemporal Dementia -- CADASIL: Molecular Mechanisms and Animal Models -- Spontaneously Hypertensive Rat (SHR): An Animal Model of Vascular Brain Disorder -- Animals Models of Normal Pressure Hydrocephalus -- Animal Models of Traumatically-Induced Dementia -- Animal Models of Alcohol-Induced Dementia -- Animal Models of Metallic Dementia.
520			_aWith an ever-increasing elderly population and the resultant rising levels of dementia-related disorders, preclinical research based on animal models is pivotal to our knowledge of underlying molecular mechanisms and drug discovery aiming at the development of therapeutic strategies alleviating or preventing the neurological devastation. In Animal Models of Dementia, expert researchers provide contributions that stress the importance of extensively validated animal models in drug discovery and development in order to predict clinical activity. Beginning with general aspects of animal modeling, related ethical issues, and essential methodological considerations, the highly detailed volume then continues with various levels of model validation, including pathological, behavioral, neurochemical, pharmacological, and imaging aspects, followed by sections focused on specific disorders, such as Alzheimer's disease, Parkinson's disease, metachromatic leukodystrophy and adrenoleukodystrophy, amyotrophic lateral sclerosis, frontotemporal dementia as well as vascular dementia and more. As a volume in the renowned Neuromethods series, this book offers a detailed, yet accessible, overview of currently available animal models in the field of dementia research, and touches, as well, upon more general areas linked to the development and use of animal models. Comprehensive and efficient, Animal Models of Dementia will significantly aid both experienced animal researchers as well as investigators on the verge of beginning animal model-based dementia research.
988			_aSpringer_Protocols_2011
650		7	_2embne _9141806 _aDemencia _xModelos animales
650		7	_2embne _9185363 _aCerebro _xEnfermedades _xModelos animales
776	0	8	_iPrinted edition: _z9781607618973
776	0	8	_iPrinted edition: _z9781607618997
776	0	8	_iPrinted edition: _z9781493961184
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-60761-898-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b09/2023 _dz _eb _zSI