000			04242nam a22004095i 4500
999			_c392015 _d392015
001			392015
003			ES-MaUEC
005			20231013094224.0
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007			cr nn 008mamaa
008			100301s2004 xxu| o |||| 0|eng d
020			_a9781592597888
024	7		_a10.1385/1592597882 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC268.5 _b2004 EB
245	0	0	_aCheckpoint Controls and Cancer : _bVolume 1: Reviews and Model Systems _cedited by Axel H. Schönthal
250			_a1st edition 2004
264		1	_aTotowa, NJ _bHumana Press _c2004
300			_a1 recurso en línea (XVI, 318 páginas)
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v280
505	0		_aReviews of Checkpoint Controls, Their Involvement in the Development of Cancer, and Approaches to Their Investigation -- G1 and S-Phase Checkpoints, Chromosome Instability, and Cancer -- Analyzing the G2/M Checkpoint -- Analyzing the Spindle Checkpoint in Yeast and Frogs -- Cell Cycle Checkpoint Control Mechanisms That Can Be Disrupted in Cancer -- Analyzing Checkpoint Controls in Diverse Model Systems -- Establishment of a Cell-Free System to Study the Activation of Chk2 -- Analyzing Checkpoint Controls in Human Skin -- Generation and Analysis of Brca1 Conditional Knockout Mice -- Analysis of Cell Cycle Progression and Genomic Integrity in Early Lethal Knockouts -- Xenopus Cell-Free Extracts to Study the DNA Damage Response -- A Xenopus Cell-Free System for Functional Analysis of the Chfr Ubiquitin Ligase Involved in Control of Mitotic Entry -- Control of Mitotic Entry After DNA Damage in Drosophila -- Methods for Analyzing Checkpoint Responses in Caenorhabditis elegans -- Assaying the Spindle Checkpoint in the Budding Yeast Saccharomyces cerevisiae -- Purification and Analysis of Checkpoint Protein Complexes From Saccharomyces cerevisiae.
520			_aIntracellular checkpoint controls constitute a network of signal transduction pathways that protect cells from external stresses and internal errors by means of cell cycle arrest, DNA repair, or apoptosis. Failure of this machinery can lead to embryonic death, genetic diseases, and cancer. In Checkpoint Controls and Cancer, Volume 1: Reviews and Model Systems, Axel H. Schönthal, PhD, marshals a prestigious panel of researchers working at the cutting edges of their fields to comprehensively review the complexities of checkpoint controls and the model systems available to study them. The authors introduce all of the important components of checkpoint controls, describe their intricate interactions, and highlight the relevance of these processes to the cancer problem. Additional chapters illustrate the advantages of using such diverse model systems as intact human skin, knockout mice, Xenopus, and yeast, and show how they can cross-fertilize and accelerate research both across disciplines and beyond the boundaries of a particular species. A second volume, Activation and Regulation Protocols, provides readily reproducible experimental protocols for studying the molecular components of checkpoint controls and their regulation. Comprehensive and up-to-date, the two volumes of Checkpoint Controls and Cancer offer novice and experienced researchers alike not only entré into the complexities of this vast field, but also to the full panoply of productive tools needed to deepen understanding of the systems, as well as to develop new and more effective cancer therapies.
988			_aSpringer_Protocols_2004
650		7	_2embne _9146492 _aCarcinogénesis
650		7	_2embne _9273952 _aCáncer _xAspectos genéticos
776	0	8	_iPrinted edition: _z9781617374265
776	0	8	_iPrinted edition: _z9781588292148
776	0	8	_iPrinted edition: _z9781489943651
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1385/1592597882 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b10/2023 _dz _eIG _zSI