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020			_a9781071612545
024	7		_a10.1007/978-1-0716-1254-5 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRM322 _b2021 EB
245	0	0	_aExperimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy _cedited by Divya Vohora
250			_a1st edition 2021
264		1	_aNew York, NY _bSpringer International Publising _c2021
300			_a1 recurso en línea (XIV, 250 páginas) _b37 ilustraciones, 24 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aNeuromethods _x1940-6045 _v167
505	0		_aModels of Seizures and Epilepsy: Important Tools in the Discovery and Evaluation of Novel Epilepsy Therapies -- Protocol for Rodent Organotypic Hippocampal Slice Culture Model for Ex Vivo Monitoring of Epileptogenesis -- Methods for the Screening of New Chemical Entities for Deciphering Neuroinflammatory and Associated Pathways in Seizures: An In Vitro Perspective -- Cellular Electrophysiological Methods to Decipher the Altered Synaptic Transmission Associated with Drug Resistant Epilepsy -- Acute Seizure Tests Used in Epilepsy Research: Step-by-Step Protocol of the Maximal Electroshock Seizure (MES) Test, The Maximal Electroshock Seizure Threshold (MEST) Test, and the Pentylenetetrazole (PTZ)-Induced Seizure Test in Rodents -- Procedures for Electrical and Chemical Kindling Models in Rats and Mice -- Methods for the Induction of status epilepticus and Temporal Lobe Epilepsy in Rodents: The Kainic Acid and the Pilocarpine Model -- Seizure Monitoring in Rodents -- Protocol for 6Hz Corneal Stimulation in Rodents for Refractory Seizures -- A Method to Induce Lamotrigine-Resistant Corneal Kindled Mice -- Protocol for Drug Screening with Quantitative Video-Electroencephalography in a Translational Model of Refractory Neonatal Seizures -- Methods to Investigate Seizures and Associated Cognitive Decline using Zebrafish Model -- C. elegans as a Potential Model for Acute Seizure-Like Activity.
520			_aThis volume discusses the latest experimental and clinical approaches to study seizures and epilepsy. Chapters in this book cover detailed protocols for ex vivo and in vitro experimental models and widely-used in vivo (acute and chronic seizure) models in epilepsy research. Chapters also cover techniques to screen the effective leads for the treatment of refractory seizures of pharmacoresistant epilepsy and invertebrate, non-mammalian models. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and practical, Experimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy is a valuable resource for researchers, in both industry and academia, interested in learning about this important and developing field.
988			_aSpringer_Protocols_2021
650		7	_2embne _9144280 _aAnticonvulsivos
650		7	_2embne _9140489 _aEpilepsia _xTratamiento
776	0	8	_iPrinted edition: _z9781071612538
776	0	8	_iPrinted edition: _z9781071612552
776	0	8	_iPrinted edition: _z9781071612569
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-0716-1254-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b07/2023 _dz _eb _zSI