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008			210521s2021 xxua o |||| 0|eng d
020			_a9781071614761
024	7		_a10.1007/978-1-0716-1476-1 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQH431 _b2021 EB
245	0	4	_aThe Myc Gene : _bMethods and Protocols _cedited by Laura Soucek, Jonathan Whitfield
250			_a2nd edition 2021
264		1	_aNew York, NY _bSpringer International Publising _c2021
300			_a1 recurso en línea (XIV, 349 páginas) _b53 ilustraciones, 44 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v2318
505	0		_aAn "-omycs" Toolbox to Work with MYC -- Methods of Expression, Purification and Preparation of the c-Myc b-HLH-LZ for its Biophysical Characterization -- Biophysical and Structural Methods to Study the bHLHzip Region of Human c-MYC -- Identifying and Validating MYC:protein Interactors in Pursuit of Novel anti-MYC Therapies -- Detection of Post-Translational Modifications on MYC -- MYC Analysis in Cancer and Evolution -- Genome-wide analysis of c-MYC-regulated mRNAs and miRNAs, and c-MYC DNA-binding by Next Generation Sequencing -- Analysis of Myc Chromatin Binding by Calibrated ChIP-seq Approach -- A High-Throughput Chromatin Immunoprecipitation Sequencing Approach to Study the Role of MYC on the Epigenetic Landscape -- Methods for Determining Myc-induced Apoptosis -- Measuring MYC-mediated Metabolism in Tumorigenesis -- Methods to study Myc-regulated Cellular Senescence - An Update -- Examining Myc-Dependent Translation Changes in Cellular Homeostasis and Cancer -- A Versatile in vivo System to Study Myc in Cell Reprogramming -- Using Flow Cytometry to Study Myc's Role in Shaping the Tumor Immune Microenvironment -- Generation of a Tetracycline Regulated Mouse Model of MYC-Induced T-Cell Acute Lymphoblastic Leukemia -- Chromogenic in Situ Hybridization (CISH) as a Method for Detection of C-Myc Amplification in Formalin-Fixed Paraffin-Embedded Tumor Tissue: An Update -- MYC Copy Number Detection in Clinical Samples using a Digital DNA-Hybridization and Detection Method -- Cell-Based Methods for the Identification of Myc-Inhibitory Small Molecules.
520			_aThis second edition provides new and updated chapters detailing recent advances in MYC research and current techniques. Chapters guide readers through protocols on how to express and purify MYC protein, X-ray crystallography, NMR, techniques to study how MYC is modified, apoptosis, senescence, proliferation, metabolic changes, translation, tumorigenesis,reprogramming, and clinical application of MYC studies.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, The Myc Gene: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.
988			_aSpringer_Protocols_2021
650		7	_2embne _9140562 _aGenética humana _vManuales de laboratorio
650		7	_2embne _9158538 _aOncogenes _vManuales de laboratorio
776	0	8	_iPrinted edition: _z9781071614754
776	0	8	_iPrinted edition: _z9781071614778
776	0	8	_iPrinted edition: _z9781071614785
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-0716-1476-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b08/2023 _dz _eb _zSI