000			04057nam a22003975i 4500
999			_c391312 _d391312
001			391312
003			ES-MaUEC
005			20230511110416.0
006			a||||fo|||| 00| 0
007			cr nn 008mamaa
008			130906s2013 xxu| s |||| 0|eng d
020			_a9781627036528
024	7		_a10.1007/978-1-62703-652-8 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQP552 .P4 _b2013 EB
245	0	0	_aPeptide Modifications to Increase Metabolic Stability and Activity _cedited by Predrag Cudic
250			_a1st edition 2013
264		1	_aTotowa, NJ _bHumana Press _c2013
300			_a1 recurso en línea (IX, 241 páginas) _b92 ilustraciones, 16 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v1081
505	0		_aHantzsch Based Macrocyclization Approach for the Synthesis of Thiazole Containing Cyclopeptides -- The Chemical Synthesis of α-Conotoxins and Structurally Modified Analogs with Enhanced Biological Stability -- Synthesis of AApeptides -- Peptoids and Peptide - Peptoid Hybrid Biopolymers as Peptidomimetics -- Synthesis of Side Chain N,N'-diaminoalkylated Derivatives of Basic Amino Acids for Application in Solid-phase Peptide Synthesis -- Study Protein Folding and Aggregation Using Non-natural Amino Acid p-cyanophenylalanine as a Sensitive Optical Probe -- AdamantoyLated Biologically Active Small Peptides and Glycopeptides Structurally Related to the Bacterial Peptidoglycan -- Optimization of Physicochemical and Pharmacological Properties of Peptide Drugs by Glycosylation -- The Maillard Reaction Induced Modification of Endogenous Opioid Peptide Encephalin -- Solid-phase Guanidinylation of Peptidyl Amines Compatible with Standard Fmoc-chemistry: Formation of Monosubstituted Guanidines -- Stabilization of Collagen-Model, Triple-Helical Peptides for In Vitro and In Vivo Applications -- Identification of Adipokine Receptor Agonists and Turning Them to Antagonists -- Peptide Detection and Structure Determination in Live Cells using Confocal Raman.
520			_aIn Peptide Modifications to Increase Metabolic Stability and Activity, expert researchers in the field provide summarized methods for preparation, purification of modified peptides, and assessment of their biochemical activities. These methods and protocols include preparation of conformationally constrained peptides, modification of peptide bonds, introduction of nonproteinogenic amino acids, and alteration of peptides' physical and biological properties by modification of the amino acid side chains and/or terminal residues. With additional chapter that describes new experimental approach for the detection of exogenous peptides within living cells using peptides labeled with heavy isotopes and confocal Raman microscopy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.   Authoritative and practical, Peptide Modifications to Increase Metabolic Stability and Activity seeks to provide scientists with alternative approaches to peptide modification that many researchers may find applicable to their specific research requirements.
988			_aSpringer_Protocols_2013
650		7	_2embne _9146243 _aPéptidos _xManuales de laboratorio
776	0	8	_iPrinted edition: _z9781627036535
776	0	8	_iPrinted edition: _z9781627036511
776	0	8	_iPrinted edition: _z9781493962846
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-62703-652-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b05/2023 _dz _eu _zSI