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008			220606s2022 sz | o |||| 0|eng d
020			_a9783031791772
024	7		_a10.1007/978-3-031-79177-2 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQP623.5 .S63 _b2022 EB
100	1		_aMirzaei, Hamed _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9688403
245	1	0	_aExosomes and MicroRNAs in Biomedical Science _cby Hamed Mirzaei, Neda Rahimian, Hamid Reza Mirzaei, Javid Sadri Nahand, Michael R. Hamblin
250			_a1st edition 2022
264		1	_aCham _bSpringer International Publishing _c2022
300			_a1 recurso en línea (IV, 175 páginas)
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aSynthesis Lectures on Biomedical Engineering _x1930-0336
520			_aMicroRNAs (miRNAs) are a member of the family of non-coding RNA molecules, and consist of small conserved sequences between 19-25 nucleotides in length that are responsible for regulating many cellular functions by affecting a wide range of messenger RNAs in a sequence specific manner. Fundamental biological processes like cell proliferation and growth, stress resistance, tumorigenesis, fat metabolism, and neural development have all been shown to be governed by miRNAs. miRNAs carry out the post-transcriptional silencing of gene expression via targeting the 30-untranslated region (UTR) of the complementary mRNA sequence. The dysregulation of the expression levels of various miRNAs is typical of tumor cells, and has been associated with tumor progression and poor prognosis. Many miRNAs are up-regulated in cancer, where they can silence tumor suppressor genes such as apoptosis and immune response associated genes. Therefore, it is possible to profile the expression levels of miRNAs as biomarkers, in order to diagnose cancer and noncancerous diseases. Moreover, cancer detection in the early stages is crucial in clinical situations. Characterization of miRNAs in serum, plasma, and other bodily fluids, and understanding their stability against RNase degradation, is important to assess their suitability as biomarkers and diagnostic tools. Exosomes play an important role in inter-cellular communications, and these nanosized particles have various functions in diverse physiological pathways, in normal as well as abnormal cells. Exosomes can carry diverse cargos such as mRNAs, miRNAs, and proteins that transfer information between donor and recipient cells. Furthermore, uptake of exosomes and their cargos may promote or suppress various molecular and cellular pathways, which alter the cellular behavior. Many reports have discussed the role of exosomes released from cancer cells on the progression of cancer at various stages. Exosomes and their cargos may affect the growth of the tumor, metastasis, drug resistance, immune system function, as well as angiogenesis. Therefore, exosomes have been explored as diagnostic biomarkers in many cancers. Moreover, exosomes can be used as biological vehicles to deliver different drugs and agents like doxorubicin (DOX), miRNAs, and siRNAs. The present book covers the role of exosomes and micro-RNAs in the pathogenesis and treatment of various diseases.
988			_aSynthesis Collection of Technology_2022
650		7	_2embne _9144940 _aARN
650		7	_2embne _9162605 _aGenomas
650		7	_2embne _9143729 _aCiencias biomédicas
700	1		_aRahimian, Neda _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9688404
700	1		_aMirzaei, Hamid Reza _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9688405
700	1		_aNahand, Javid Sadri _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9688406
700	1		_aHamblin, Michael R _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut
776	0	8	_iPrinted edition: _z9783031791826
776	0	8	_iPrinted edition: _z9783031791727
776	0	8	_iPrinted edition: _z9783031791871
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-031-79177-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b05/2023 _dz _eb _zSI