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007			cr nn 008mamaa
008			220601s2010 sz | s |||| 0|eng d
020			_a9783031025808
024	7		_a10.1007/978-3-031-02580-8 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRD771.I6 _b2010 EB
100	1		_aGrad, Sibylle _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9687778
245	1	0	_aCells and Biomaterials for Intervertebral Disc Regeneration _cby Sibylle Grad, Mauro Alini, David Eglin, Daisuke Sakai, Joji Mochida, Sunil Mahor, Biraja Dash, Abhay Pandit, Estelle Collin
250			_a1st edition 2010
264		1	_aCham _bSpringer International Publishing _c2010
300			_a1 recurso en línea (VIII, 96 páginas)
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aSynthesis Lectures on Tissue Engineering _x1944-0308
520			_aDisorders related to the intervertebral disc (IVD) are common causes of morbidity and of severe life quality deterioration. IVD degeneration, although in many cases asymptomatic, is often the origin of painful neck and back diseases. In Western societies IVD related pain and disability account for enormous health care costs as a result of work absenteeism and thus lost production, disability benefits, medical and insurance expenses. Although only a small percentage of patients with disc disorders finally will undergo surgery, spinal surgery has been one of the fastest growing disciplines in the musculoskeletal field in recent years. Nevertheless, current treatment options are still a matter of controversial discussion. In particular, they hardly can restore normal spine biomechanics and prevent degeneration of adjacent tissues. While degeneration affects all areas of the IVD, the most constant and noticeable changes occur in the gel-like central part, the nucleus pulposus (NP). Recent emphasis has therefore been put in biological ways to regenerate the NP; however, there are a number of obstacles to overcome, considering the exceptional biological and biomechanical environment of this tissue. Different biological approaches such as molecular, gene, and cell based therapies have been investigated and have shown promising results in both in vitro and in vivo studies. Nonetheless, considerable hurdles still exist in their application for IVD regeneration in human patients. The choice of the cells and the choice of the cell carrier suitable for implantation pose major challenges for research and development activities. This lecture recapitulates the basics of IVD structure, function, and degeneration mechanisms. The first part reviews the recent progress in the field of disc and stem cell based regenerative approaches. In the second part, most appropriate biomaterials that have been evaluated as cell or molecule carrier to cope with degenerative disc disease are outlined. The potential and limitations of cell- and biomaterial-based treatment strategies and perspectives for future clinical applications are discussed. Table of Contents: Cell Therapy for Nucleus Pulposus Regeneration / Recent Advances in Biomaterial Based Tissue Engineering for Intervertebral Disc Regeneration.
988			_aSynthesis Collection of Technology_2010
650		7	_2embne _9677239 _aDiscos intervertebrales _xEnfermedades _xTratamiento
650		7	_2embne _9148273 _aRegeneración (Biología)
650		7	_2embne _9668849 _aTejidos (Biología)
700	1		_aAlini, Mauro _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9687779
700	1		_aEglin, David _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9687781
700	1		_aSakai, Daisuke _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9687782
700	1		_aMochida, Joji _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9687783
700	1		_aMahor, Sunil _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9687788
700	1		_aDash, Biraja _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9687789
700	1		_aPandit, Abhay _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9687790
700	1		_aCollin, Estelle _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9687791
776	0	8	_iPrinted edition: _z9783031014529
776	0	8	_iPrinted edition: _z9783031037085
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-031-02580-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b03/2023 _dz _esc _zSI