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999			_c387602 _d387602
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003			ES-MaUEC
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007			cr nn 008mamaa
008			220601s2010 sz | s |||| 0|eng d
020			_a9783031025785
024	7		_a10.1007/978-3-031-02578-5 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQM142 _b2010 EB
100	1		_aAthanasiou, K. A. _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9687765 _q(Kyriacos A.)
245	1	0	_aArticular Cartilage Tissue Engineering _cby Kyriacos Athanasiou, Eric M. Darling, Jerry C. Hu
250			_a1st edition 2010
264		1	_aCham _bSpringer International Publishing _c2010
300			_a1 recurso en línea (X, 174 páginas)
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aSynthesis Lectures on Tissue Engineering _x1944-0308
505	0		_aHyaline Articular Cartilage -- Cartilage Aging and Pathology -- In Vitro -- Bioreactors -- Future Directions.
520			_aCartilage injuries in children and adolescents are increasingly observed, with roughly 20% of knee injuries in adolescents requiring surgery. In the US alone, costs of osteoarthritis (OA) are in excess of $65 billion per year (both medical costs and lost wages). Comorbidities are common with OA and are also costly to manage. Articular cartilage's low friction and high capacity to bear load makes it critical in the movement of one bone against another, and its lack of a sustained natural healing response has necessitated a plethora of therapies. Tissue engineering is an emerging technology at the threshold of translation to clinical use. Replacement cartilage can be constructed in the laboratory to recapitulate the functional requirements of native tissues. This book outlines the biomechanical and biochemical characteristics of articular cartilage in both normal and pathological states, through development and aging. It also provides a historical perspective of past and current cartilage treatments and previous tissue engineering efforts. Methods and standards for evaluating the function of engineered tissues are discussed, and current cartilage products are presented with an analysis on the United States Food and Drug Administration regulatory pathways that products must follow to market. This book was written to serve as a reference for researchers seeking to learn about articular cartilage, for undergraduate and graduate level courses, and as a compendium of articular cartilage tissue engineering design criteria. Table of Contents: Hyaline Articular Cartilage / Cartilage Aging and Pathology / In Vitro / Bioreactors / Future Directions.
988			_aSynthesis Collection of Technology_2010
650		7	_2embne _9139084 _aBioingeniería
650		7	_2embne _9668288 _aCartílago articular
650		7	_2embne _9668849 _aTejidos (Biología)
700	1		_aDarling, Eric M. _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9687767
700	1		_aHu, Jerry C. _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9687769
776	0	8	_iPrinted edition: _z9783031014505
776	0	8	_iPrinted edition: _z9783031037061
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-031-02578-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b03/2023 _dz _esc _zSI