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008			220601s2009 sz | s |||| 0|eng d
020			_a9783031025693
024	7		_a10.1007/978-3-031-02569-3 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQH442 _b2009 EB
100	1		_aKuldell, Natalie _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9687755
245	1	0	_aGenome Refactoring _cby Natalie Kuldell, Neal Lerner
250			_a1st edition 2009
264		1	_aCham _bSpringer International Publishing _c2009
300			_a1 recurso en línea (XII, 66 páginas)
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aSynthesis Lectures on Synthetic Biology _x2151-0016
505	0		_aTools for Genome Engineering and Synthetic Biology -- Bacteriophage as Templates for Refactoring -- Methods/Teaching Protocols for M13 Reengineering -- Writing and Speaking as Biological Engineers -- Summary and Future Directions -- Appendix A -- Appendix B -- Appendix C.
520			_aThe science of biology celebrates the discovery and understanding of biological systems that already exist in nature. In parallel, the engineering of biology must learn how to make use of our understanding of the natural world to design and build new useful biological systems. ""Synthetic biology"" represents one example of recent work to engineer biological systems. This emerging field aims to replace the ad hoc process of assembling biological systems by primarily developing tools to assemble reliable-but-complex living organisms from standard components that can later be reused in new combination. The focus of this book is ""genome refactoring,"" one of several approaches to manage the complexity of a biological system in which the goal is to redesign the genetic elements that encode a living form--preserving the function of that form but encoding it with a genome far easier to study and extend. This book presents genome refactoring in two ways: as an important aspect of the emerging field of synthetic biology and as a powerful teaching tool to train would be professionals in the subject. Chapters focus on the overarching goals of synthetic biology and their alignment with the motivations and achievements in genome engineering; the engineering frameworks of refactoring, including genome synthesis, standardization of biological parts, and abstraction; a detailed description of the bacteriophages that have been refactored up to this point; and the methods of refactoring and contexts for that work drawn from the bacteriophage M13. Overall, these examples offer readers the potential for synthetic biology and the areas in need of further research. If successful, synthetic biology and genome refactoring could address any number of persistent societal needs, including sustainable energy, affordable and effective medicine, and green manufacturing practices. Table of Contents: Tools for Genome Engineering and Synthetic Biology / Bacteriophage as Templates for Refactoring / Methods/Teaching Protocols for M13 Reengineering / Writing and Speaking as Biological Engineers / Summary and Future Directions / Appendix A / Appendix B / Appendix C.
988			_aSynthesis Collection of Technology_2009
650		7	_2embne _9141520 _aIngeniería genética
650		7	_2embne _9140445 _aVirus _xGenética
650		7	_2embne _9671714 _aBacteriófagos _xGenética
700	1		_aLerner, Neal _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9687756
776	0	8	_iPrinted edition: _z9783031014413
776	0	8	_iPrinted edition: _z9783031036972
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-031-02569-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b03/2023 _dz _esc _zSI